HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: GRB7 (Q14451)
Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Gene: GRB7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	10803466
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3, BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0030335 - positive regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 532
+	Hs
		439730 INSR_HUMAN (1-1382): 0: 1513: 100.00		GRB14_HUMAN (12-532): 0: 618: 47.91
+	Rn
		313142 T2CB11_RAT (1-1382): 0: 1524: 94.73		GRB14_RAT (12-532): 0: 605: 46.96
+	Rn
		313139 INSR_RAT (1-1382): 0: 1513: 94.29		GRB14_RAT (12-532): 0: 605: 46.96
+	Hs
		439723 INSR_HUMAN (1-1382): 0: 1513: 100.00		GRB10_HUMAN (1-532): 0: 596: 53.17
+	Hs
		465520 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		GRB14_HUMAN (12-532): 0: 618: 47.91
+	Hs
		465509 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		GRB10_HUMAN (1-532): 0: 596: 53.17
+	Hs
		439632 INSR_HUMAN (1-1382): 0: 1513: 100.00		VAV_HUMAN (84-526): 1.15e-86: 286: 15.27
+	Hs
		439876 INSR_HUMAN (1-1382): 0: 1513: 100.00		VAV3_HUMAN (81-526): 1.29e-62: 221: 10.44
+	Hs
		439636 INSR_HUMAN (1-1382): 0: 1513: 100.00		PLCG1_HUMAN (200-532): 4.01e-50: 187: 14.69
+	Rn
		531971 INSR_RAT (1-1382): 0: 1513: 94.29		PLCG1_RAT (200-532): 5.95e-50: 187: 14.97
+	Mm
		431318 INSR_MOUSE (1-1382): 0: 1494: 94.22		SRC_MOUSE (351-528): 1.56e-46: 172: 24.32
+	Hs
		439674 INSR_HUMAN (1-1382): 0: 1513: 100.00		CSK_HUMAN (394-525): 1.95e-28: 119: 28.78
+	Hs
		439698 INSR_HUMAN (1-1382): 0: 1513: 100.00		GRB2_HUMAN (427-513): 2.67e-13: 71: 29.89
+	Mm
		581963 INSR_MOUSE (1-1382): 0: 1494: 94.22		GRB10_MOUSE (2-77): 8.38e-13: 73: 33.33
+	Hs
		465690 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		VAV3_HUMAN (81-526): 1.29e-62: 221: 10.44
+	Hs
		463279 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		LYN_HUMAN (347-531): 1.7e-49: 180: 18.46
+	Hs
		465388 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		SRC_HUMAN (351-528): 1.08e-46: 172: 24.32
+	Hs
		465445 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		MATK_HUMAN (398-525): 4.8e-36: 142: 30.37
+	Hs
		465442 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		CSK_HUMAN (394-525): 1.95e-28: 119: 28.78
+	Hs
		465477 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		GRB2_HUMAN (427-513): 2.67e-13: 71: 29.89