HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: STYX (Q8WUJ0)
Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein)
Gene: STYX

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.80	0.625

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DSPc~fn3
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 223
+	Hs
		326647 INSR_HUMAN (1-1382): 0: 1513: 100.00		DUS14_HUMAN (7-185): 1.9e-63: 197: 31.84
+	Hs
		439804 INSR_HUMAN (1-1382): 0: 1513: 100.00		SSH1_HUMAN (10-201): 3.16e-56: 194: 28.13
+	Hs
		439793 INSR_HUMAN (1-1382): 0: 1513: 100.00		DUS18_HUMAN (10-185): 1.36e-58: 184: 26.71
+	Hs
		439798 INSR_HUMAN (1-1382): 0: 1513: 100.00		DUS19_HUMAN (32-187): 3.45e-55: 177: 33.97
+	Hs
		465586 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		STYX_HUMAN (1-223): 3.2e-91: 268: 100.00
+	Hs
		326648 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		DUS14_HUMAN (7-185): 1.9e-63: 197: 31.84
+	Hs
		572947 INSRR_HUMAN (13-1341): 0: 1272: 51.98		STYX_HUMAN (1-223): 3.2e-91: 268: 100.00
+	Hs
		465590 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		SSH1_HUMAN (10-201): 3.16e-56: 194: 28.13
+	Hs
		465644 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		DUS15_HUMAN (32-198): 2.97e-58: 187: 33.53
+	Hs
		465580 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		DUS18_HUMAN (10-185): 1.36e-58: 184: 26.71
+	Hs
		465549 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		DUS29_HUMAN (22-174): 1.12e-56: 180: 30.77
+	Hs
		465634 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		DUS26_HUMAN (27-176): 7.86e-57: 180: 30.46
+	Hs
		465585 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		DUS19_HUMAN (32-187): 3.45e-55: 177: 33.97
+	Hs
		465649 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		DUS21_HUMAN (19-185): 3.02e-55: 176: 26.95
+	Hs
		710646 EPHA3_HUMAN (529-1319): 0: 596: 21.57		STYX_HUMAN (1-223): 3.2e-91: 268: 100.00
+	Hs
		1147391 EPHA7_HUMAN (529-1356): 0: 577: 20.53		STYX_HUMAN (1-223): 3.2e-91: 268: 100.00
+	Hs
		710641 EPHA3_HUMAN (529-1319): 0: 596: 21.57		DUS18_HUMAN (10-185): 1.36e-58: 184: 26.71
+	Hs
		710661 EPHA3_HUMAN (529-1319): 0: 596: 21.57		DUS21_HUMAN (19-185): 3.02e-55: 176: 26.95
+	Hs
		1147384 EPHA7_HUMAN (529-1356): 0: 577: 20.53		DUS18_HUMAN (10-185): 1.36e-58: 184: 26.71
+	Hs
		1147419 EPHA7_HUMAN (529-1356): 0: 577: 20.53		DUS26_HUMAN (27-176): 7.86e-57: 180: 30.46