HitPredict

Interactor 1: RU2B (P08579)
U2 small nuclear ribonucleoprotein B'' (U2 snRNP B'')
Gene: SNRPB2

Interactor 2: PPIE (Q9UNP9)
Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)
Gene: PPIE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pro_isomerase~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck GO:0071007 - U2-type catalytic step 2 spliceosome and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 225 Hs			1 301
+	Hs
		446841 SNRPA_HUMAN (2-225): 2.91e-42: 146: 48.56		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		1020353 ELAV2_HUMAN (128-224): 1.33e-15: 76.3: 19.61		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		236134 HNRPQ_HUMAN (4-224): 8.43e-14: 71.6: 20.00		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		516744 PABP1_HUMAN (141-225): 2.1e-13: 70.5: 17.78		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		321252 PTBP3_HUMAN (4-224): 2.96e-13: 70.1: 15.35		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		203484 PTBP3_HUMAN (4-224): 2.96e-13: 70.1: 15.35		PPIH_HUMAN (131-300): 1.25e-91: 271: 55.11