HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.648

Property	Details
Experiments	29721183, 31694235
Identification Methods	affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 164
+	Hs
		449735 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35
+	Hs
		449696 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		449707 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34
+	Hs
		266899 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		516365 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Mm
		857305 HMGB1_MOUSE (1-174): 9.92e-46: 152: 100.00		TIA1_MOUSE (5-107): 1.59e-18: 82.6: 21.70
+	Hs
		449708 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44
+	Hs
		703374 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		CSTF2_HUMAN (10-110): 1.87e-25: 103: 25.47
+	Hs
		853869 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14
+	Hs
		817819 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14
+	Hs
		996647 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		SRSF9_HUMAN (9-82): 1.91e-19: 83.2: 40.79
+	Hs
		818011 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09
+	Hs
		1298805 TOX2_HUMAN (91-183): 1.82e-20: 90.6: 26.88		CSTFT_HUMAN (10-110): 1.69e-24: 100: 24.53
+	Hs
		996648 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44
+	Hs
		818009 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		SRSF9_HUMAN (9-82): 1.91e-19: 83.2: 40.79
+	Hs
		680429 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		TIA1_HUMAN (5-107): 1.38e-18: 83: 21.70
+	Hs
		818421 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		RBM4_HUMAN (11-88): 3.45e-18: 81.9: 28.21
+	Hs
		817926 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		TIAR_HUMAN (1-95): 5.6e-18: 81.1: 26.00
+	Hs
		817968 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		SRSF4_HUMAN (11-112): 3.43e-16: 76.6: 39.22
+	Sc
		376710 IXR1_YEAST (79-174): 6.78e-16: 77.4: 23.96		PABP_YEAST (2-93): 6.85e-19: 84.2: 20.62