HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: PRP8 (Q6P2Q9)
Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220)
Gene: PRPF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	29721183, 35235311
Identification Methods	affinity chromatography technology, cross-linking study, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0071222 - cellular response to lipopolysaccharide
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 2335
+	Hs
		996718 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		PRP8_HUMAN (1-2335): 0: 4632: 100.00
+	Hs
		818165 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		PRP8_HUMAN (1-2335): 0: 4632: 100.00
+	Hs
		1159244 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		PRP8_HUMAN (1-2335): 0: 4632: 100.00