HitPredict

Interactor 1: ADRB2 (P07550)
Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
Gene: ADRB2

Interactor 2: GRK6 (P43250)
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
Gene: GRK6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	9819198, 8672451, 24561123
Identification Methods	enzymatic study, pull down, protein complementation assay, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	7tm_1~Pkinase
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 413 Hs			1 576
+	Hs
		458298 ADRB2_HUMAN (1-413): 2.61e-118: 352: 100.00		GRK5_HUMAN (1-563): 7.91e-177: 514: 71.76
+	Hs
		458295 ADRB2_HUMAN (1-413): 2.61e-118: 352: 100.00		GRK4_HUMAN (1-575): 1.8e-170: 497: 65.34
+	Hs
		458413 ADRB2_HUMAN (1-413): 2.61e-118: 352: 100.00		GRK1_HUMAN (3-537): 3.44e-155: 458: 47.96
+	Hs
		458283 ADRB2_HUMAN (1-413): 2.61e-118: 352: 100.00		ARBK1_HUMAN (2-533): 4.25e-146: 439: 36.95
+	Hs
		458303 ADRB2_HUMAN (1-413): 2.61e-118: 352: 100.00		ARBK2_HUMAN (2-545): 1.92e-144: 434: 36.04
+	Hs
		669218 NK1R_HUMAN (9-412): 6.35e-70: 227: 20.87		GRK5_HUMAN (1-563): 7.91e-177: 514: 71.76
+	Mm
		424698 ADRB1_MOUSE (50-411): 2.18e-77: 249: 48.72		KAPCA_MOUSE (144-500): 1.48e-144: 423: 28.57
+	Hs
		605547 DRD1_HUMAN (15-385): 6.22e-76: 244: 31.39		KAPCA_HUMAN (144-500): 2.71e-145: 424: 28.85
+	Hs
		603160 DRD1_HUMAN (15-385): 6.22e-76: 244: 31.39		KPCA_HUMAN (176-496): 1.88e-58: 208: 38.08