HitPredict

Interactor 1: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Interactor 2: PTPRK (Q15262)
Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)
Gene: PTPRK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0016477 - cell migration GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1439
+	Hs
		962070 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		PTPRK_HUMAN (26-1439): 0: 1175: 100.00
+	Hs
		961995 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		PTPRJ_HUMAN (345-1438): 2.64e-111: 385: 16.25
+	Hs
		988321 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		PTPRJ_HUMAN (345-1438): 2.64e-111: 385: 16.25
+	Hs
		466226 RHOC_HUMAN (1-193): 7.6e-80: 237: 100.00		PTPRJ_HUMAN (345-1438): 2.64e-111: 385: 16.25
+	Hs
		1015394 RHOG_HUMAN (1-193): 2.26e-78: 233: 54.92		PTPRJ_HUMAN (345-1438): 2.64e-111: 385: 16.25
+	Hs
		955102 CDC42_HUMAN (1-193): 8.86e-78: 232: 51.30		PTPRJ_HUMAN (345-1438): 2.64e-111: 385: 16.25
+	Hs
		581013 RAC2_HUMAN (1-193): 2.92e-77: 231: 54.12		PTPRJ_HUMAN (345-1438): 2.64e-111: 385: 16.25
+	Hs
		705696 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		PTPRM_HUMAN (11-1145): 2.16e-66: 249: 12.76
+	Hs
		522635 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		PTPRF_HUMAN (3-825): 1.83e-64: 244: 13.85
+	Hs
		522641 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		PTPRF_HUMAN (3-825): 1.83e-64: 244: 13.85
+	Hs
		466080 RHOC_HUMAN (1-193): 7.6e-80: 237: 100.00		PTPRF_HUMAN (3-825): 1.83e-64: 244: 13.85
+	Hs
		522650 RHOG_HUMAN (1-193): 2.26e-78: 233: 54.92		PTPRF_HUMAN (3-825): 1.83e-64: 244: 13.85
+	Hs
		522632 CDC42_HUMAN (1-193): 8.86e-78: 232: 51.30		PTPRF_HUMAN (3-825): 1.83e-64: 244: 13.85
+	Hs
		522584 RAC2_HUMAN (1-193): 2.92e-77: 231: 54.12		PTPRF_HUMAN (3-825): 1.83e-64: 244: 13.85
+	Hs
		659007 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		PTPRG_HUMAN (902-1147): 9.58e-46: 183: 29.64
+	Hs
		659013 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		PTPRG_HUMAN (902-1147): 9.58e-46: 183: 29.64
+	Hs
		962011 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		PTPRS_HUMAN (264-819): 1.33e-22: 108: 9.69
+	Hs
		988333 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		PTPRS_HUMAN (264-819): 1.33e-22: 108: 9.69
+	Hs
		466235 RHOC_HUMAN (1-193): 7.6e-80: 237: 100.00		PTPRS_HUMAN (264-819): 1.33e-22: 108: 9.69
+	Hs
		955122 CDC42_HUMAN (1-193): 8.86e-78: 232: 51.30		PTPRS_HUMAN (264-819): 1.33e-22: 108: 9.69