HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: PTPRJ (Q12913)
Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)
Gene: PTPRJ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0019901 - protein kinase binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1337
+	Hs
		988321 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		PTPRJ_HUMAN (1-1337): 0: 929: 100.00
+	Hs
		601258 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		PTPRJ_HUMAN (1-1337): 0: 929: 100.00
+	Hs
		953413 RAC3_HUMAN (1-191): 4.97e-80: 238: 89.01		PTPRJ_HUMAN (1-1337): 0: 929: 100.00
+	Hs
		988333 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		PTPRS_HUMAN (12-1093): 2.99e-96: 343: 12.57
+	Hs
		601268 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		PTPRS_HUMAN (12-1093): 2.99e-96: 343: 12.57
+	Hs
		953423 RAC3_HUMAN (1-191): 4.97e-80: 238: 89.01		PTPRS_HUMAN (12-1093): 2.99e-96: 343: 12.57
+	Hs
		522641 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		PTPRF_HUMAN (189-970): 1.88e-83: 304: 14.35
+	Hs
		522584 RAC2_HUMAN (1-192): 1.14e-83: 247: 100.00		PTPRF_HUMAN (189-970): 1.88e-83: 304: 14.35
+	Hs
		389259 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		FINC_HUMAN (111-907): 4.35e-81: 297: 19.00
+	Hs
		522588 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		PTPRF_HUMAN (189-970): 1.88e-83: 304: 14.35
+	Hs
		522631 RAC3_HUMAN (1-191): 4.97e-80: 238: 89.01		PTPRF_HUMAN (189-970): 1.88e-83: 304: 14.35
+	Hs
		601397 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		NEO1_HUMAN (271-1127): 2.41e-78: 287: 10.88
+	Hs
		659013 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		PTPRG_HUMAN (757-1329): 3.87e-54: 210: 17.51
+	Hs
		601175 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		PTPRG_HUMAN (757-1329): 3.87e-54: 210: 17.51
+	Hs
		611077 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		PTN1_HUMAN (1033-1290): 1.73e-55: 201: 36.84
+	Hs
		580865 RAC2_HUMAN (1-192): 1.14e-83: 247: 100.00		PTN1_HUMAN (1033-1290): 1.73e-55: 201: 36.84
+	Hs
		611064 RAC3_HUMAN (1-191): 4.97e-80: 238: 89.01		PTN1_HUMAN (1033-1290): 1.73e-55: 201: 36.84
+	Hs
		601299 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		PTPRK_HUMAN (25-498): 9.98e-29: 127: 11.87
+	Hs
		953461 RAC3_HUMAN (1-191): 4.97e-80: 238: 89.01		PTPRK_HUMAN (25-498): 9.98e-29: 127: 11.87
+	Hs
		705696 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		PTPRM_HUMAN (114-507): 1.22e-19: 98.1: 10.17