HitPredict

Interactor 1: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Interactor 2: SNX27 (Q96L92)
Sorting nexin-27
Gene: SNX27

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31871319, 34315543
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras, RA~Ras
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 541
+	Hs
		988531 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		SNX31_HUMAN (161-541): 5.39e-130: 388: 21.43
+	Hs
		955183 CDC42_HUMAN (1-193): 8.86e-78: 232: 51.30		SNX17_HUMAN (162-535): 1.89e-107: 331: 25.31
+	Hs
		962627 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		NEB1_HUMAN (40-375): 5.45e-38: 151: 13.85
+	Hs
		988818 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		NEB1_HUMAN (40-375): 5.45e-38: 151: 13.85
+	Hs
		466522 RHOC_HUMAN (1-193): 7.6e-80: 237: 100.00		NEB1_HUMAN (40-375): 5.45e-38: 151: 13.85
+	Hs
		1015902 RHOG_HUMAN (1-193): 2.26e-78: 233: 54.92		NEB1_HUMAN (40-375): 5.45e-38: 151: 13.85
+	Hs
		955747 CDC42_HUMAN (1-193): 8.86e-78: 232: 51.30		NEB1_HUMAN (40-375): 5.45e-38: 151: 13.85
+	Mm
		1247224 RHOA_MOUSE (1-193): 1.03e-81: 242: 92.23		NEB2_MOUSE (40-314): 1.76e-33: 137: 17.98
+	Mm
		988893 RAC1_MOUSE (1-193): 6.84e-81: 240: 57.22		NEB2_MOUSE (40-314): 1.76e-33: 137: 17.98
+	Hs
		955505 CDC42_HUMAN (1-193): 8.86e-78: 232: 51.30		NEB2_HUMAN (40-314): 6.2e-34: 138: 17.98
+	Mm
		953805 CDC42_MOUSE (1-193): 8.86e-78: 232: 51.30		NEB2_MOUSE (40-314): 1.76e-33: 137: 17.98
+	Hs
		270704 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		LDB3_HUMAN (42-359): 1.45e-30: 128: 11.52
+	Hs
		167687 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		LIN7A_HUMAN (35-136): 1.9e-28: 115: 33.98
+	Mm
		1193967 RHOA_MOUSE (1-193): 1.03e-81: 242: 92.23		SHAN3_MOUSE (44-148): 2.58e-21: 100: 36.19
+	Mm
		988884 RAC1_MOUSE (1-193): 6.84e-81: 240: 57.22		SHAN3_MOUSE (44-148): 2.58e-21: 100: 36.19
+	Hs
		962401 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		MAGI1_HUMAN (2-294): 7.49e-14: 76.9: 15.29
+	Hs
		988627 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		MAGI1_HUMAN (2-294): 7.49e-14: 76.9: 15.29
+	Hs
		961986 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		ZO1_HUMAN (4-254): 4.46e-12: 71.1: 13.60
+	Hs
		955496 CDC42_HUMAN (1-193): 8.86e-78: 232: 51.30		MAGI1_HUMAN (2-294): 7.49e-14: 76.9: 15.29
+	Hs
		955091 CDC42_HUMAN (1-193): 8.86e-78: 232: 51.30		ZO1_HUMAN (4-254): 4.46e-12: 71.1: 13.60