HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: NEB1 (Q9ULJ8)
Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A)
Gene: PPP1R9A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0007015 - actin filament organization GO:0030425 - dendrite
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1098
+	Hs
		581371 RAC2_HUMAN (1-192): 2.74e-81: 241: 92.19		NEB1_HUMAN (1-1098): 2.87e-121: 401: 100.00
+	Hs
		1433576 RHOJ_HUMAN (2-189): 1.39e-80: 240: 60.64		NEB1_HUMAN (1-1098): 2.87e-121: 401: 100.00
+	Hs
		953756 RAC3_HUMAN (1-191): 3.71e-78: 233: 93.19		NEB1_HUMAN (1-1098): 2.87e-121: 401: 100.00
+	Hs
		955747 CDC42_HUMAN (1-192): 5.32e-78: 232: 70.31		NEB1_HUMAN (1-1098): 2.87e-121: 401: 100.00
+	Hs
		988325 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		DLG1_HUMAN (225-1097): 5.12e-73: 263: 13.80
+	Hs
		581014 RAC2_HUMAN (1-192): 2.74e-81: 241: 92.19		DLG1_HUMAN (225-1097): 5.12e-73: 263: 13.80
+	Hs
		1091569 RHOJ_HUMAN (2-189): 1.39e-80: 240: 60.64		DLG1_HUMAN (225-1097): 5.12e-73: 263: 13.80
+	Hs
		953416 RAC3_HUMAN (1-191): 3.71e-78: 233: 93.19		DLG1_HUMAN (225-1097): 5.12e-73: 263: 13.80
+	Hs
		955106 CDC42_HUMAN (1-192): 5.32e-78: 232: 70.31		DLG1_HUMAN (225-1097): 5.12e-73: 263: 13.80
+	Hs
		953602 RAC3_HUMAN (1-191): 3.71e-78: 233: 93.19		DLG3_HUMAN (311-1098): 6.1e-72: 258: 12.79
+	Mm
		988891 RAC1_MOUSE (1-192): 4.32e-85: 250: 100.00		DLG4_MOUSE (376-1098): 2.53e-57: 213: 13.40
+	Mm
		1189508 Q3TLP8_MOUSE (1-192): 1.47e-80: 240: 90.52		DLG4_MOUSE (376-1098): 2.53e-57: 213: 13.40
+	Mm
		988893 RAC1_MOUSE (1-192): 4.32e-85: 250: 100.00		NEB2_MOUSE (1-824): 1.22e-44: 176: 43.40
+	Mm
		953805 CDC42_MOUSE (1-192): 5.32e-78: 232: 70.31		NEB2_MOUSE (1-824): 1.22e-44: 176: 43.40
+	Hs
		955505 CDC42_HUMAN (1-192): 5.32e-78: 232: 70.31		NEB2_HUMAN (1-824): 3.57e-44: 175: 45.39
+	Hs
		988322 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		PTN13_HUMAN (2-1014): 2.76e-18: 93.5: 11.74
+	Hs
		936282 CDC42_HUMAN (1-192): 5.32e-78: 232: 70.31		AFAD_HUMAN (419-593): 1.97e-23: 110: 30.11
+	Hs
		1090181 RHOJ_HUMAN (2-189): 1.39e-80: 240: 60.64		PTN13_HUMAN (2-1014): 2.76e-18: 93.5: 11.74
+	Hs
		953414 RAC3_HUMAN (1-191): 3.71e-78: 233: 93.19		PTN13_HUMAN (2-1014): 2.76e-18: 93.5: 11.74
+	Hs
		955103 CDC42_HUMAN (1-192): 5.32e-78: 232: 70.31		PTN13_HUMAN (2-1014): 2.76e-18: 93.5: 11.74