HitPredict

Interactor 1: CPXA (P0AE82)
Sensor histidine kinase CpxA (EC 2.7.13.3)
Gene: CPXA

Interactor 2: CPXR (P0AE88)
Transcriptional regulatory protein CpxR
Gene: CPXR

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.80	0.774

Property	Details
Experiments	24561554, 24492262, 16176121
Identification Methods	two hybrid, protein kinase assay, phosphotransferase assay, two hybrid array
Interaction Type	direct interaction, phosphorylation reaction, physical association

Property	Details
Interacting Pfam domains	HATPase_c~Response_reg, HisKA~Response_reg
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 457 Ec			1 232
+	Se
		3030 A0A0H3NUZ2_SALTS (1-457): 8.38e-160: 461: 96.94		A0A0H3NK16_SALTS (1-232): 4.48e-70: 215: 97.41
+	Ss
		937545 Q55475_SYNY3 (146-453): 7.94e-68: 223: 25.55		P72948_SYNY3 (1-229): 2.27e-75: 229: 38.20
+	Ec
		439475 PHOR_ECOLI (227-452): 1.64e-66: 220: 29.61		PHOB_ECOLI (3-228): 3.22e-72: 221: 37.83
+	Mx
		1091479 Q1D333_MYXXD (227-457): 9.73e-65: 217: 30.54		Q1DCL7_MYXXD (4-229): 2.1e-72: 221: 36.84
+	Ec
		676783 BAES_ECOLI (143-456): 3.58e-63: 213: 24.14		BAER_ECOLI (2-232): 8.71e-72: 220: 36.21
+	Mx
		1091444 Q1D333_MYXXD (227-457): 9.73e-65: 217: 30.54		Q1D1K9_MYXXD (3-231): 9.18e-68: 209: 42.17
+	Ss
		1122361 Q55941_SYNY3 (218-457): 1.71e-64: 216: 29.30		Q55942_SYNY3 (2-230): 2.74e-67: 208: 32.05
+	Ec
		467568 CUSS_ECOLI (134-452): 2.24e-67: 224: 27.30		CUSR_ECOLI (2-230): 2.88e-63: 198: 33.77
+	Mx
		1091475 Q1D333_MYXXD (227-457): 9.73e-65: 217: 30.54		Q1D8M8_MYXXD (4-232): 1.44e-64: 201: 37.07
+	Ec
		940183 HPRS_ECOLI (165-452): 2.3e-60: 205: 23.05		HPRR_ECOLI (2-230): 2.63e-68: 211: 36.96
+	Ss
		1122356 RPPB_SYNY3 (242-455): 3.89e-62: 210: 30.63		RPPA_SYNY3 (2-231): 5.89e-66: 205: 31.20
+	Mx
		1091472 Q1D333_MYXXD (227-457): 9.73e-65: 217: 30.54		Q1D6S6_MYXXD (2-231): 5.91e-63: 197: 32.33
+	Mx
		1091248 Q1CVV2_MYXXD (192-451): 2.14e-57: 204: 24.82		Q1D1K9_MYXXD (3-231): 9.18e-68: 209: 42.17
+	Mx
		1091469 Q1D333_MYXXD (227-457): 9.73e-65: 217: 30.54		Q1D334_MYXXD (1-230): 8.04e-62: 194: 35.47
+	Mx
		1091327 Q1CWW4_MYXXD (127-455): 1.82e-58: 207: 21.37		Q1D8M8_MYXXD (4-232): 1.44e-64: 201: 37.07
+	Cv
		1308003 Q9A913_CAUVC (110-452): 7.27e-66: 220: 28.57		Q9A912_CAUVC (3-231): 8.7e-58: 185: 35.78
+	Mx
		1091371 Q1D333_MYXXD (227-457): 9.73e-65: 217: 30.54		Q1CYI6_MYXXD (4-232): 6.08e-58: 185: 35.19
+	Mx
		1091315 Q1CWW4_MYXXD (127-455): 1.82e-58: 207: 21.37		Q1CYI6_MYXXD (4-232): 6.08e-58: 185: 35.19
+	Ss
		937876 Q55783_SYNY3 (243-456): 1.73e-63: 212: 24.78		P73104_SYNY3 (3-221): 3.97e-53: 171: 30.05
+	Ec
		576107 RSTB_ECOLI (8-456): 4.01e-60: 204: 25.06		RSTA_ECOLI (1-232): 7.24e-55: 177: 32.07