HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	38334954, 39358380, 22939624
Identification Methods	cross-linking study, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~PK_Tyr_Ser-Thr
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0045793 - positive regulation of cell size
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 1114
+	Hs
		461078 HS90A_HUMAN (1-732): 0: 1085: 100.00		FGFR1_HUMAN (359-1061): 1.49e-150: 472: 28.97
+	Hs
		461151 HS90A_HUMAN (1-732): 0: 1085: 100.00		FGFR3_HUMAN (501-1061): 1.99e-148: 466: 33.16
+	Rn
		1013218 HS90A_RAT (1-732): 0: 1083: 97.95		Q9QX70_RAT (426-1113): 1.35e-141: 459: 23.48
+	Hs
		461521 HS90A_HUMAN (1-732): 0: 1085: 100.00		NTRK3_HUMAN (336-1018): 1.53e-144: 456: 21.48
+	Hs
		461214 HS90A_HUMAN (1-732): 0: 1085: 100.00		VGFR2_HUMAN (344-1105): 1.12e-138: 454: 23.45
+	Hs
		179592 HS90A_HUMAN (1-732): 0: 1085: 100.00		MUSK_HUMAN (396-1018): 1.28e-142: 453: 25.16
+	Hs
		461499 HS90A_HUMAN (1-732): 0: 1085: 100.00		ERBB4_HUMAN (426-1087): 3.85e-135: 444: 21.68
+	Hs
		411201 HS90A_HUMAN (1-732): 0: 1085: 100.00		NTRK1_HUMAN (403-1018): 1.42e-139: 442: 24.17
+	Hs
		410528 HS90A_HUMAN (1-732): 0: 1085: 100.00		ERBB2_HUMAN (426-1113): 1.08e-134: 441: 24.86
+	Rn
		1013217 HS90A_RAT (1-732): 0: 1083: 97.95		Q8K3F9_RAT (426-1113): 2.68e-133: 438: 24.03
+	Hs
		362613 HS90A_HUMAN (1-732): 0: 1085: 100.00		EGFR_HUMAN (421-1113): 1.58e-132: 434: 22.19
+	Hs
		179593 HS90B_HUMAN (19-732): 0: 1057: 86.13		MUSK_HUMAN (396-1018): 1.28e-142: 453: 25.16
+	Hs
		461531 HS90A_HUMAN (1-732): 0: 1085: 100.00		NTRK2_HUMAN (590-1018): 1.63e-124: 403: 30.74
+	Hs
		461149 HS90A_HUMAN (1-732): 0: 1085: 100.00		FGFR4_HUMAN (535-1054): 2.05e-123: 399: 37.89
+	Hs
		461310 HS90A_HUMAN (1-732): 0: 1085: 100.00		EPHB1_HUMAN (604-1031): 1.17e-110: 370: 28.51
+	Hs
		91885 HS90B_HUMAN (19-732): 0: 1057: 86.13		C9JYL6_HUMAN (506-664): 2.26e-113: 350: 98.74
+	Hs
		461213 HS90A_HUMAN (1-732): 0: 1085: 100.00		VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25
+	Hs
		456121 HS90A_HUMAN (1-732): 0: 1085: 100.00		CSF1R_HUMAN (706-1018): 4.93e-74: 267: 40.22
+	Hs
		461218 HS90A_HUMAN (1-732): 0: 1085: 100.00		FLT3_HUMAN (714-1014): 2.21e-72: 262: 40.00
+	Hs
		461209 HS90A_HUMAN (1-732): 0: 1085: 100.00		TIE1_HUMAN (693-1019): 5.9e-71: 260: 44.24