HitPredict

Interactor 1: H2AB1 (P0C5Y9)
Histone H2A-Bbd type 1 (H2A Barr body-deficient) (H2A.B) (H2A.Bbd)
Gene: H2AB1

Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 115 Hs			1 2089
+	Hs
		555463 H2AX_HUMAN (7-109): 6.03e-51: 159: 47.57		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		555435 H2AX_HUMAN (7-109): 6.03e-51: 159: 47.57		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		470364 H2A1_HUMAN (7-109): 4.1e-50: 156: 45.63		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		391676 H2A1B_HUMAN (7-109): 7.99e-50: 155: 44.66		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Mm
		650186 H2AX_MOUSE (7-109): 9.45e-51: 159: 47.57		MDC1_MOUSE (519-2089): 3.52e-71: 267: 22.06
+	Hs
		555337 H2AX_HUMAN (7-109): 6.03e-51: 159: 47.57		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		801336 H2A1J_HUMAN (7-109): 1.01e-50: 158: 45.63		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		555515 H2AX_HUMAN (7-109): 6.03e-51: 159: 47.57		PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56
+	Sp
		392005 H2A2_SCHPO (21-109): 1.1e-19: 79.7: 48.32		BRC1_SCHPO (1619-2075): 2.14e-66: 245: 16.94
+	Sp
		391995 H2A1_SCHPO (21-109): 2.92e-19: 78.6: 48.32		BRC1_SCHPO (1619-2075): 2.14e-66: 245: 16.94
+	Hs
		1264786 H2A1H_HUMAN (7-109): 2.18e-50: 157: 45.63		TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72
+	Hs
		470480 H2A1_HUMAN (7-109): 4.1e-50: 156: 45.63		TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72
+	Hs
		391817 H2A1B_HUMAN (7-109): 7.99e-50: 155: 44.66		TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72
+	Hs
		555503 H2AX_HUMAN (7-109): 6.03e-51: 159: 47.57		NIPBL_HUMAN (869-1889): 2.17e-21: 104: 15.13
+	Sp
		144286 H2A1_SCHPO (21-109): 2.92e-19: 78.6: 48.32		MDB1_SCHPO (1662-2081): 8.94e-44: 172: 12.12
+	Hs
		1273164 H2A1H_HUMAN (7-109): 2.18e-50: 157: 45.63		PRG4_HUMAN (260-1225): 4.33e-17: 90.5: 9.80
+	Hs
		470625 H2A1_HUMAN (7-109): 4.1e-50: 156: 45.63		PRC2C_HUMAN (145-1944): 8.04e-16: 86.5: 8.07
+	Hs
		554260 H2AX_HUMAN (7-109): 6.03e-51: 159: 47.57		MUC1_HUMAN (762-1525): 1.68e-11: 72: 18.23