Protein: NCOA5
Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA)

Gene: NCOA5
Organism: Homo sapiens
Interactions: 128
UniProt ID: Q9HCD5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003682 - chromatin binding
GO:0003714 - transcription corepressor activity
GO:0003723 - RNA binding
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1438828

NCOA5
Nuclear receptor coactivator 5

3

7

High-throughput

0.660

High

786861

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

3

1

High-throughput

0.650

High

794632

RBMX
RNA-binding motif protein, X chromosome

3

0

High-throughput

0.638

High

1219147

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

3

3

High-throughput

0.637

High

655343

SFPQ
Splicing factor, proline- and glutamine-rich

2

1

High-throughput

0.628

High

889663

CLK2
Dual specificity protein kinase CLK2

2

1

High-throughput

0.628

High

1414537

HTAI2
Protein HTATIP2

3

1

Small-scale

0.612

High

846483

MATR3
Matrin-3

2

1

High-throughput

0.611

High

1235529

IFIX
Pyrin and HIN domain-containing protein 1

2

1

High-throughput

0.611

High

1438829

LRC4C
Leucine-rich repeat-containing protein 4C

2

0

High-throughput

0.602

High

485426

ROA1
Heterogeneous nuclear ribonucleoprotein A1

2

0

High-throughput

0.585

High

480313

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.576

High

765906

BMI1
Polycomb complex protein BMI-1

2

0

High-throughput

0.547

High

166197

AIM2
Interferon-inducible protein AIM2

1

1

High-throughput

0.536

High

462648

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

3

High-throughput

0.536

High

478212

SNRPA
U1 small nuclear ribonucleoprotein A

1

2

High-throughput

0.536

High

542230

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

968453

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

1

High-throughput

0.536

High

1160091

SRSF7
Serine/arginine-rich splicing factor 7

1

2

High-throughput

0.536

High

1399755

RBM14
RNA-binding protein 14

1

2

High-throughput

0.536

High

1438846

TNPO3
Transportin-3

1

1

High-throughput

0.536

High

344330

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.513

High

574479

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

660732

IF4B
Eukaryotic translation initiation factor 4B

1

0

High-throughput

0.513

High

775321

FUS
RNA-binding protein FUS

1

0

High-throughput

0.513

High

788213

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

948590

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1065439

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1099548

SRSF6
Serine/arginine-rich splicing factor 6

1

0

High-throughput

0.513

High

1111877

TRA2A
Transformer-2 protein homolog alpha

1

0

High-throughput

0.513

High

1116026

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

1160304

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

1365676

LAR4B
La-related protein 4B

1

0

High-throughput

0.513

High

1405190

MPP8
M-phase phosphoprotein 8

1

0

High-throughput

0.513

High

1429462

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

0

High-throughput

0.513

High

1438844

TPX2
Targeting protein for Xklp2

1

0

High-throughput

0.513

High

1438845

FAN1
Fanconi-associated nuclease 1

1

0

High-throughput

0.513

High

284718

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

1

3

High-throughput

0.481

High

1225080

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

1

High-throughput

0.481

High

260480

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

373200

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

685738

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.479

High

980362

H4
Histone H4

1

1

High-throughput

0.479

High

1088567

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

2

High-throughput

0.479

High

1132987

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

2

High-throughput

0.479

High

1290741

ZCH18
Zinc finger CCCH domain-containing protein 18

1

2

High-throughput

0.479

High

1369848

CELF1
CUGBP Elav-like family member 1

1

1

High-throughput

0.479

High

1387572

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

1

High-throughput

0.479

High

1438835

RNC
Ribonuclease 3

1

1

High-throughput

0.479

High

123444

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.460

High

1203618

ZN326
DBIRD complex subunit ZNF326

1

0

High-throughput

0.460

High

1420016

UBL5
Ubiquitin-like protein 5

1

0

High-throughput

0.460

High

130618

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.458

High

143272

NFIB
Nuclear factor 1 B-type

1

0

High-throughput

0.458

High

223346

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

242990

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

378522

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.458

High

396985

ESR1
Estrogen receptor

1

0

Small-scale

0.458

High

905162

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

1107232

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1127174

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

1135113

CUL7
Cullin-7

1

0

High-throughput

0.458

High

1152644

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.458

High

1156864

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1162700

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

0

Small-scale

0.458

High

1289311

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.458

High

1311864

DHX40
Probable ATP-dependent RNA helicase DHX40

1

0

High-throughput

0.458

High

1314704

SRRM1
Serine/arginine repetitive matrix protein 1

1

0

High-throughput

0.458

High

1328963

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.458

High

1339183

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1352763

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1381732

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

1385631

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1417480

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1438831

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

0

High-throughput

0.458

High

1438832

ANLN
Anillin

1

0

High-throughput

0.458

High

1438836

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1438840

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.458

High

1438841

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1438842

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.458

High

1059970

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

3

High-throughput

0.457

High

1180027

CCD57
Coiled-coil domain-containing protein 57

1

1

High-throughput

0.439

High

1433943

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1438843

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

442809

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.426

High

530398

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

1089882

ILF3
Interleukin enhancer-binding factor 3

1

0

High-throughput

0.426

High

1108401

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.426

High

1119312

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1130464

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1428368

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.407

High

1433203

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

High-throughput

0.407

High

1438839

WRP73
WD repeat-containing protein WRAP73

1

2

Small-scale

0.407

High

1410806

NUD12
NAD-capped RNA hydrolase NUDT12

3

0

High-throughput

0.347

High

932417

GALC
Galactocerebrosidase

3

0

High-throughput

0.342

High

1392918

NTAQ1
Protein N-terminal glutamine amidohydrolase

3

0

High-throughput

0.331

High

158670

TYB4Y
Thymosin beta-4, Y-chromosomal

1

0

High-throughput

0.279

Low

271580

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.279

Low

1360750

JPH3
Junctophilin-3

1

0

High-throughput

0.279

Low

1384725

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

1387897

PABP5
Polyadenylate-binding protein 5

1

0

High-throughput

0.279

Low

1401811

PEO1
Twinkle mtDNA helicase

1

0

High-throughput

0.279

Low

1412237

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.279

Low

1438837

TM14B
Transmembrane protein 14B

1

0

High-throughput

0.279

Low

348749

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.269

Low

1152477

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.265

Low

1158554

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.265

Low

1153508

RAB30
Ras-related protein Rab-30

1

0

High-throughput

0.251

Low

1165353

SYT16
Synaptotagmin-16

1

0

High-throughput

0.251

Low

1187689

T10IP
Testis-specific protein 10-interacting protein

1

0

High-throughput

0.251

Low

1206385

MEIG1
Meiosis expressed gene 1 protein homolog

1

0

High-throughput

0.251

Low

1272350

ATOSB
Atos homolog protein B

1

0

High-throughput

0.251

Low

1436686

GORS2
Golgi reassembly-stacking protein 2

1

0

High-throughput

0.251

Low

1438833

PICK1
PRKCA-binding protein

1

0

High-throughput

0.251

Low

157876

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

272474

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

774638

BASI
Basigin

1

0

High-throughput

0.249

Low

947283

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.249

Low

1255623

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1292035

AMZ2
Archaemetzincin-2

1

0

High-throughput

0.249

Low

1387339

OTUB2
Ubiquitin thioesterase OTUB2

1

0

Small-scale

0.249

Low

1409552

B9D2
B9 domain-containing protein 2

1

0

High-throughput

0.249

Low

1438830

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

0

High-throughput

0.249

Low

1438838

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

1438834

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

1400143

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.232

Low

1436754

GHC1
Mitochondrial glutamate carrier 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025