HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: BRAP (Q7Z569)
BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63)
Gene: BRAP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	25820252, 28768733, 28190767, 38803224, 17550899
Identification Methods	two hybrid, pull down, enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_2, ubiquitin~zf-UBP
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 592
+	Hs
		476644 UBC_HUMAN (1-685): 0: 846: 100.00		UBP16_HUMAN (273-583): 1.82e-65: 230: 18.82
+	Hs
		475461 UBC_HUMAN (1-685): 0: 846: 100.00		UBP5_HUMAN (228-564): 2.66e-63: 225: 15.14
+	Hs
		476599 UBC_HUMAN (1-685): 0: 846: 100.00		UBP20_HUMAN (296-560): 3.22e-62: 223: 15.75
+	Hs
		476097 UBC_HUMAN (1-685): 0: 846: 100.00		UBP33_HUMAN (297-554): 5.21e-61: 219: 17.22
+	Hs
		476658 UBC_HUMAN (1-685): 0: 846: 100.00		UBP3_HUMAN (281-584): 4.08e-63: 218: 14.58
+	Hs
		475957 UBC_HUMAN (1-685): 0: 846: 100.00		UBP45_HUMAN (272-583): 8.15e-59: 212: 13.51
+	Hs
		476145 UBC_HUMAN (1-685): 0: 846: 100.00		UBP13_HUMAN (228-566): 2.87e-53: 197: 12.04
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (310-583): 4.54e-48: 177: 13.04
+	Hs
		476067 UBC_HUMAN (1-685): 0: 846: 100.00		UBP32_HUMAN (349-586): 4.39e-40: 159: 13.55
+	Hs
		476624 UBC_HUMAN (1-685): 0: 846: 100.00		UBP15_HUMAN (423-569): 1.13e-36: 148: 9.93
+	Hs
		476505 UBC_HUMAN (1-685): 0: 846: 100.00		HDAC6_HUMAN (301-392): 2.71e-31: 131: 24.49
+	Dm
		477538 UBIQP_DROME (1-610): 0: 752: 99.84		NOT_DROME (289-552): 1.05e-45: 170: 11.99
+	Sc
		477261 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		ETP1_YEAST (59-568): 7.53e-127: 386: 30.84
+	Sc
		477245 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP14_YEAST (273-531): 7.03e-41: 160: 17.90
+	At
		1091780 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBP14_ARATH (241-569): 1.9e-45: 173: 13.07
+	Hs
		800571 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		UBP5_HUMAN (228-564): 2.66e-63: 225: 15.14
+	Mm
		476724 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP5_MOUSE (238-564): 3.18e-63: 225: 15.28
+	Mm
		476806 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP13_MOUSE (228-566): 1.16e-52: 195: 12.04
+	Mm
		101489 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP32_MOUSE (349-586): 8.97e-40: 158: 13.55
+	Hs
		924205 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		HDAC6_HUMAN (301-392): 2.71e-31: 131: 24.49