HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP37 (Q86T82)
Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37)
Gene: USP37

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.948

Property	Details
Experiments	29576527, 31699778, 38803224, 28327663, 23287719, 24324262
Identification Methods	pull down, unspecified method, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UCH~ubiquitin, UIM~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 979
+	Hs
		475693 UBC_HUMAN (1-685): 0: 846: 100.00		UBP4_HUMAN (237-952): 2.53e-132: 424: 16.23
+	Hs
		475502 UBC_HUMAN (1-685): 0: 846: 100.00		UBP11_HUMAN (242-964): 9.67e-127: 409: 14.30
+	Hs
		476624 UBC_HUMAN (1-685): 0: 846: 100.00		UBP15_HUMAN (237-955): 2.37e-121: 395: 14.19
+	Hs
		476097 UBC_HUMAN (1-685): 0: 846: 100.00		UBP33_HUMAN (206-976): 2.35e-95: 324: 12.42
+	Hs
		476599 UBC_HUMAN (1-685): 0: 846: 100.00		UBP20_HUMAN (201-977): 7.09e-89: 306: 13.65
+	Hs
		475461 UBC_HUMAN (1-685): 0: 846: 100.00		UBP5_HUMAN (109-750): 2.81e-88: 303: 12.55
+	Hs
		476644 UBC_HUMAN (1-685): 0: 846: 100.00		UBP16_HUMAN (193-950): 2.39e-86: 297: 13.09
+	Hs
		476658 UBC_HUMAN (1-685): 0: 846: 100.00		UBP3_HUMAN (290-602): 3.2e-69: 242: 22.77
+	Hs
		475932 UBC_HUMAN (1-685): 0: 846: 100.00		U17L2_HUMAN (747-978): 2.35e-44: 170: 16.81
+	Hs
		271022 UBC_HUMAN (1-685): 0: 846: 100.00		UBP2_HUMAN (670-957): 6.6e-42: 165: 11.95
+	Dm
		477538 UBIQP_DROME (1-610): 0: 752: 99.84		NOT_DROME (300-664): 1.23e-75: 259: 19.90
+	Hs
		475440 UBC_HUMAN (1-685): 0: 846: 100.00		UBP8_HUMAN (697-949): 1.03e-38: 158: 14.79
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (661-956): 1.53e-36: 147: 13.48
+	Hs
		475566 UBC_HUMAN (1-685): 0: 846: 100.00		UBP46_HUMAN (761-952): 1.24e-32: 132: 18.45
+	Hs
		301354 UBC_HUMAN (1-685): 0: 846: 100.00		UBP19_HUMAN (511-716): 4.41e-27: 121: 18.06
+	Hs
		476545 UBC_HUMAN (1-685): 0: 846: 100.00		UBP21_HUMAN (695-949): 7.57e-14: 77.7: 15.64
+	Hs
		64200 UBC_HUMAN (1-685): 0: 846: 100.00		UBP27_HUMAN (816-966): 1.3e-12: 73.1: 22.81
+	Hs
		259261 UBC_HUMAN (1-685): 0: 846: 100.00		UBP12_HUMAN (816-952): 9.02e-11: 66.9: 21.85
+	At
		1210479 UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80		UBP15_ARATH (646-973): 1.07e-38: 158: 15.43
+	Sc
		477294 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP5_YEAST (338-593): 1.22e-53: 203: 24.13