HitPredict

Interactor 1: GNAI3 (P08754)
Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)
Gene: GNAI3

Interactor 2: GPSM1 (Q86YR5)
G-protein-signaling modulator 1 (Activator of G-protein signaling 3)
Gene: GPSM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.952

Property	Details
Experiments	21209316, 12719437, 26186194, 28514442, 33961781, unassigned3799
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	G-alpha~GoLoco
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016239 - positive regulation of macroautophagy
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 354 Hs			1 675
+	Hs
		989851 GNAI1_HUMAN (1-354): 4.67e-179: 502: 93.79		GPSM1_HUMAN (1-675): 2.85e-146: 442: 100.00
+	Hs
		989828 GNAI1_HUMAN (1-354): 4.67e-179: 502: 93.79		GPSM2_HUMAN (14-660): 1.56e-119: 374: 57.27
+	Hs
		475948 GNAI3_HUMAN (1-354): 1.48e-176: 495: 100.00		GPSM2_HUMAN (14-660): 1.56e-119: 374: 57.27
+	Hs
		418649 GNAI2_HUMAN (1-354): 2.83e-174: 489: 85.92		GPSM2_HUMAN (14-660): 1.56e-119: 374: 57.27
+	Mm
		617648 GNAO_MOUSE (1-354): 4.75e-168: 473: 70.70		GPSM2_MOUSE (14-660): 6.87e-119: 372: 57.89
+	Hs
		989852 GNAI1_HUMAN (1-354): 4.67e-179: 502: 93.79		PCP2_HUMAN (490-591): 8.2e-27: 108: 36.28
+	Hs
		475991 GNAI3_HUMAN (1-354): 1.48e-176: 495: 100.00		PCP2_HUMAN (490-591): 8.2e-27: 108: 36.28
+	Hs
		418699 GNAI2_HUMAN (1-354): 2.83e-174: 489: 85.92		PCP2_HUMAN (490-591): 8.2e-27: 108: 36.28
+	Mm
		475858 GNAI2_MOUSE (1-354): 6.7e-173: 486: 85.35		PCP2_MOUSE (490-591): 1.13e-26: 106: 34.31
+	Mm
		554287 GNAO_MOUSE (1-354): 4.75e-168: 473: 70.70		PCP2_MOUSE (490-591): 1.13e-26: 106: 34.31
+	Ce
		908540 GNAO_CAEEL (1-354): 1.17e-166: 470: 69.86		Q19955_CAEEL (204-653): 2.62e-17: 87.8: 14.95
+	Dm
		631760 GNAI_DROME (1-354): 3.44e-164: 464: 76.90		Q9NFR7_DROME (26-177): 9e-17: 86.3: 29.87
+	Dm
		631761 GNAI_DROME (1-354): 3.44e-164: 464: 76.90		Q9VB22_DROME (26-177): 1.84e-16: 85.1: 29.87
+	Dm
		594797 GNAO_DROME (1-354): 1.52e-161: 457: 69.01		Q9VB22_DROME (26-177): 1.84e-16: 85.1: 29.87
+	Hs
		618435 GNAZ_HUMAN (1-353): 7.69e-156: 443: 67.23		STIP1_HUMAN (112-460): 5.86e-16: 83.5: 13.51