HitPredict

Interactor 1: IFIT1 (P09914)
Antiviral innate immune response effector IFIT1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56) (Interferon-induced protein with tetratricopeptide repeats 1)
Gene: IFIT1

Interactor 2: IFIT5 (Q13325)
Interferon-induced protein with tetratricopeptide repeats 5 (IFIT-5) (Interferon-induced 58 kDa protein) (Retinoic acid- and interferon-inducible 58 kDa protein) (P58)
Gene: IFIT5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	38334954, 21642987
Identification Methods	cross-linking study, affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	TPR_10~TPR_12, TPR_12~TPR_12, TPR_12~TPR_8, TPR_2~TPR_2, TPR_2~TPR_8, TPR_8~TPR_8
Common GO terms	GO:0003723 - RNA binding GO:0005829 - cytosol GO:0045071 - negative regulation of viral genome replication GO:0051607 - defense response to virus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 478 Hs			1 482
+	Hs
		488179 IFIT1_HUMAN (1-478): 2.34e-93: 292: 100.00		IFT1B_HUMAN (1-467): 4.72e-105: 322: 55.44
+	Hs
		166749 IFIT1_HUMAN (1-478): 2.34e-93: 292: 100.00		IFIT3_HUMAN (1-481): 5.65e-88: 279: 41.58
+	Hs
		166789 IFT1B_HUMAN (1-469): 2.21e-92: 290: 68.02		IFIT3_HUMAN (1-481): 5.65e-88: 279: 41.58
+	Hs
		166782 IFIT5_HUMAN (3-477): 3.85e-83: 266: 55.37		IFIT3_HUMAN (1-481): 5.65e-88: 279: 41.58
+	Hs
		166795 Q8IZ03_HUMAN (3-465): 2.95e-68: 227: 44.75		IFIT3_HUMAN (1-481): 5.65e-88: 279: 41.58
+	Hs
		166748 IFIT2_HUMAN (3-465): 4.14e-67: 224: 44.75		IFIT3_HUMAN (1-481): 5.65e-88: 279: 41.58
+	Hs
		488092 IFIT1_HUMAN (1-478): 2.34e-93: 292: 100.00		IFIT2_HUMAN (168-481): 5.42e-11: 66.4: 12.54
+	Hs
		166724 IFIT3_HUMAN (217-476): 1.57e-12: 71.4: 12.50		IFIT3_HUMAN (1-481): 5.65e-88: 279: 41.58
+	Sc
		577519 CYC8_YEAST (2-389): 3.42e-37: 147: 9.34		CYC8_YEAST (321-482): 1.8e-16: 84.5: 17.22
+	Hs
		185814 OGT1_HUMAN (24-233): 1.4e-24: 109: 14.76		NPHP3_HUMAN (102-481): 1.14e-13: 76: 16.71
+	Mm
		1274369 OGT1_MOUSE (24-233): 1.14e-24: 109: 14.76		NPHP3_MOUSE (169-481): 1.38e-13: 75.6: 18.16
+	Hs
		718503 CDC27_HUMAN (295-477): 2.62e-13: 74.5: 12.77		CDC27_HUMAN (1-247): 1.35e-24: 109: 13.77
+	Hs
		185261 OGT1_HUMAN (24-233): 1.4e-24: 109: 14.76		KDM6A_HUMAN (233-482): 1.42e-11: 69.1: 14.29
+	Hs
		185255 OGT1_HUMAN (24-233): 1.4e-24: 109: 14.76		OGT1_HUMAN (309-482): 2.87e-11: 67.9: 12.07
+	Hs
		194485 KDM6A_HUMAN (12-290): 1.18e-15: 82.2: 10.04		KDM6A_HUMAN (233-482): 1.42e-11: 69.1: 14.29
+	At
		1379655 SPY_ARATH (23-223): 1.33e-12: 72.2: 13.24		SPY_ARATH (309-482): 1.77e-14: 78.3: 17.82
+	Sc
		805481 TOM71_YEAST (202-475): 8.29e-13: 72.5: 15.33		TOM71_YEAST (163-362): 1.47e-13: 74.8: 19.50