HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: GNAS1 (Q5JWF2)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas)
Gene: GNAS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	26269332
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1037
+	Hs
		496792 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNAS2_HUMAN (649-1037): 3.29e-180: 531: 93.83
+	Hs
		496793 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNAI1_HUMAN (651-1037): 4.86e-169: 501: 38.76
+	Hs
		391314 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNAI2_HUMAN (651-1037): 7.31e-168: 498: 38.76
+	Hs
		444653 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNAI3_HUMAN (651-1037): 1.17e-167: 497: 38.50
+	Hs
		450973 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNAO_HUMAN (651-1037): 1.29e-163: 487: 40.36
+	Hs
		496575 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNAQ_HUMAN (651-1037): 2.79e-160: 478: 36.43
+	Hs
		496380 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNA11_HUMAN (650-1037): 8.8e-159: 474: 37.63
+	Hs
		325959 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNA14_HUMAN (652-1037): 2.95e-156: 468: 37.31
+	Hs
		496266 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNAZ_HUMAN (651-1036): 1.41e-150: 453: 36.60
+	Mm
		70618 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		GNAI1_MOUSE (651-1037): 4.86e-169: 501: 38.76
+	Mm
		444631 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		GNAI2_MOUSE (651-1037): 1.27e-167: 497: 38.76
+	Rn
		581959 TAU_RAT (1-758): 4.86e-75: 260: 71.47		GNAO_RAT (651-1037): 1.2e-161: 481: 40.62
+	Rn
		94182 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		GNAO_RAT (651-1037): 1.2e-161: 481: 40.62
+	Mm
		497926 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		GNAQ_MOUSE (651-1037): 1.43e-160: 479: 36.43
+	Mm
		497925 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		GNA11_MOUSE (650-1037): 1.07e-158: 474: 37.63
+	Mm
		250846 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		GNAZ_MOUSE (651-1036): 8.24e-150: 451: 36.08