HitPredict

Interactor 1: MCCA (Q96RQ3)
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)
Gene: MCCC1

Interactor 2: MCCB (Q9HCC0)
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)
Gene: MCCC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.881

The method score is based on:

Property Details
Experiments 27499296, 24981860, 33961781, unassigned3799
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Biotin_carb_C~Carboxyl_trans, Biotin_lipoyl~Carboxyl_trans
Common GO terms GO:0004485 - methylcrotonoyl-CoA carboxylase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol
and 3 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 725
Hs

1 563
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Last updated: 11Aug2025