Protein: MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)

Gene: MCCB, MCCC2
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q9HCC0

Gene Ontology (top 5):
GO:0004485 - methylcrotonoyl-CoA carboxylase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1401765

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

4

18

High-throughput

0.881

High

1092653

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

4

1

High-throughput

0.694

High

242989

PRKN
E3 ubiquitin-protein ligase parkin

3

6

High-throughput

0.640

High

425850

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

18

High-throughput

0.618

High

425961

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

16

High-throughput

0.618

High

547206

PYC
Pyruvate carboxylase, mitochondrial

1

18

High-throughput

0.618

High

1094267

ACACA
Acetyl-CoA carboxylase 1

1

18

High-throughput

0.618

High

1438807

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

15

High-throughput

0.618

High

564394

CFTR
Cystic fibrosis transmembrane conductance regulator

2

2

High-throughput

0.614

High

1114352

CUL3
Cullin-3

2

1

High-throughput

0.611

High

414660

P53
Cellular tumor antigen p53

2

2

Small-scale

0.584

High

1391053

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

187409

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

2

High-throughput

0.536

High

275390

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.536

High

288261

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

1

High-throughput

0.536

High

488192

IFIT1
Antiviral innate immune response effector IFIT1

1

4

High-throughput

0.536

High

839828

EPS15
Epidermal growth factor receptor substrate 15

1

1

High-throughput

0.536

High

1123437

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.536

High

1243777

FXL19
F-box/LRR-repeat protein 19

1

1

High-throughput

0.536

High

1288377

TLK2
Serine/threonine-protein kinase tousled-like 2

1

3

High-throughput

0.536

High

1389211

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.536

High

1438817

NPS3A
Protein NipSnap homolog 3A

1

1

High-throughput

0.536

High

106676

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

373199

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.533

High

831461

CCNF
Cyclin-F

1

3

High-throughput

0.515

High

1410320

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.513

High

1156333

HSPB2
Heat shock protein beta-2

1

2

High-throughput

0.508

High

186039

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

1330569

PAF1
RNA polymerase II-associated factor 1 homolog

1

2

High-throughput

0.489

High

1353535

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

1

High-throughput

0.489

High

1384132

ARRD3
Arrestin domain-containing protein 3

1

5

High-throughput

0.489

High

1387273

HDA11
Histone deacetylase 11

1

7

High-throughput

0.489

High

1023892

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

High-throughput

0.484

High

132309

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

Small-scale

0.479

High

159868

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.479

High

176228

PER2
Period circadian protein homolog 2

1

3

Small-scale

0.479

High

282093

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

285482

EED
Polycomb protein EED

1

18

High-throughput

0.479

High

316032

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

412640

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

415877

HSPB1
Heat shock protein beta-1

1

2

Small-scale

0.479

High

537940

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

585824

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

2

High-throughput

0.479

High

609812

LEG3
Galectin-3

1

2

Small-scale

0.479

High

652581

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

4

Small-scale

0.479

High

845353

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

16

High-throughput

0.479

High

862474

YAP1
Transcriptional coactivator YAP1

1

9

High-throughput

0.479

High

951860

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

Small-scale

0.479

High

971108

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

983982

RBX1
E3 ubiquitin-protein ligase RBX1

1

3

High-throughput

0.479

High

1033786

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

1067733

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.479

High

1083761

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

1110096

HDAC1
Histone deacetylase 1

1

5

High-throughput

0.479

High

1178391

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

1194389

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

1280514

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

1327602

WDTC1
WD and tetratricopeptide repeats protein 1

1

20

High-throughput

0.479

High

1338976

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1360122

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

1

High-throughput

0.479

High

1367327

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

1381289

FBXW5
F-box/WD repeat-containing protein 5

1

2

High-throughput

0.479

High

1391180

BICD1
Protein bicaudal D homolog 1

1

2

High-throughput

0.479

High

1397446

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1403348

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

1415092

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

1

15

High-throughput

0.479

High

1428976

WWTR1
WW domain-containing transcription regulator protein 1

1

5

High-throughput

0.479

High

1435315

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1438812

WSB2
WD repeat and SOCS box-containing protein 2

1

18

High-throughput

0.479

High

1438814

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

1438818

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1438821

FBW1A
F-box/WD repeat-containing protein 1A

1

15

High-throughput

0.479

High

353564

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.470

High

294356

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

401519

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

471261

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

766870

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

784733

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.458

High

940629

ATP5E
ATP synthase F(1) complex subunit epsilon, mitochondrial

1

0

High-throughput

0.458

High

1058290

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1107231

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1281617

SLN11
Schlafen family member 11

1

0

Small-scale

0.458

High

1429847

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1438813

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

530397

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

626366

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

High-throughput

0.445

High

653581

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

935157

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

952351

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.445

High

1093187

STK4
Serine/threonine-protein kinase 4

1

6

High-throughput

0.445

High

1209682

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1226277

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.445

High

1418137

RM13
Large ribosomal subunit protein uL13m

1

2

High-throughput

0.445

High

1433202

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

3

High-throughput

0.445

High

1438823

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

5

High-throughput

0.445

High

246963

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.437

High

318885

RHBT1
Rho-related BTB domain-containing protein 1

1

4

High-throughput

0.437

High

589745

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

696562

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

769231

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

783423

TRI23
E3 ubiquitin-protein ligase TRIM23

1

7

High-throughput

0.437

High

879486

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.437

High

928555

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.437

High

965259

WDR5
WD repeat-containing protein 5

1

16

High-throughput

0.437

High

980361

H4
Histone H4

1

2

High-throughput

0.437

High

1010780

SSBP2
Single-stranded DNA-binding protein 2

1

1

Small-scale

0.437

High

1136372

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.437

High

1149994

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.437

High

1180257

SMU1
WD40 repeat-containing protein SMU1

1

20

High-throughput

0.437

High

1208961

DCA10
DDB1- and CUL4-associated factor 10

1

20

High-throughput

0.437

High

1226532

DCA15
DDB1- and CUL4-associated factor 15

1

2

High-throughput

0.437

High

1255622

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1272679

DET1
DET1 homolog

1

3

High-throughput

0.437

High

1357566

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.437

High

1384442

PF21A
PHD finger protein 21A

1

3

High-throughput

0.437

High

1429353

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.437

High

1433942

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1436800

WDR76
WD repeat-containing protein 76

1

20

High-throughput

0.437

High

1437215

NANOG
Homeobox protein NANOG

1

2

High-throughput

0.437

High

1438808

DNJC4
DnaJ homolog subfamily C member 4

1

4

High-throughput

0.437

High

1438809

NLE1
Notchless protein homolog 1

1

11

High-throughput

0.437

High

1438810

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

2

High-throughput

0.437

High

1438811

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

1438815

VSX1
Visual system homeobox 1

1

2

High-throughput

0.437

High

1438819

HOOK1
Protein Hook homolog 1

1

5

High-throughput

0.437

High

1438820

RCOR1
REST corepressor 1

1

3

High-throughput

0.437

High

1438822

ARL5A
ADP-ribosylation factor-like protein 5A

1

8

High-throughput

0.437

High

457718

TBB5
Tubulin beta chain

1

0

High-throughput

0.426

High

848080

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

0

High-throughput

0.426

High

869246

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.426

High

1135937

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

0

Small-scale

0.426

High

1387443

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.426

High

1415679

TR61B
tRNA

1

0

High-throughput

0.426

High

295635

CIB2
Calcium and integrin-binding family member 2

1

1

High-throughput

0.407

High

628465

KLK2
Kallikrein-2

1

2

High-throughput

0.407

High

1247292

WDR74
WD repeat-containing protein 74

1

20

High-throughput

0.407

High

1438816

DNJB9
DnaJ homolog subfamily B member 9

1

2

High-throughput

0.407

High

352041

RECK
Reversion-inducing cysteine-rich protein with Kazal motifs

2

0

High-throughput

0.328

High

209112

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.249

Low

458491

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.249

Low

1399199

NP1L5
Nucleosome assembly protein 1-like 5

1

0

High-throughput

0.249

Low

245008

KATIP
Katanin-interacting protein

1

0

High-throughput

0.232

Low

255217

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

430381

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

1065030

FGL1
Fibrinogen-like protein 1

1

0

High-throughput

0.232

Low

1214200

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

1233893

K0930
Uncharacterized protein KIAA0930

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025