HitPredict

Interactor 1: PCCA (Q91ZA3)
Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)
Gene: PCCA

Interactor 2: PCCB (Q99MN9)
Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)
Gene: PCCB

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29222160
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Biotin_carb_C~Carboxyl_trans, Biotin_lipoyl~Carboxyl_trans, Carboxyl_trans~PCC_BT
Common GO terms	GO:0004658 - propionyl-CoA carboxylase activity GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:1902494 - catalytic complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 724 Mm			1 541
+	Hs
		425760 PCCA_HUMAN (1-724): 0: 741: 89.15		PCCB_HUMAN (1-541): 0: 725: 92.42
+	Hs
		425950 MCCA_HUMAN (1-724): 0: 674: 36.64		PCCB_HUMAN (1-541): 0: 725: 92.42
+	Hs
		425904 ACACA_HUMAN (4-724): 0: 627: 24.87		PCCB_HUMAN (1-541): 0: 725: 92.42
+	Hs
		425850 PCCA_HUMAN (1-724): 0: 741: 89.15		MCCB_HUMAN (14-531): 0: 577: 29.87
+	Hs
		1401765 MCCA_HUMAN (1-724): 0: 674: 36.64		MCCB_HUMAN (14-531): 0: 577: 29.87
+	Dm
		1466611 Q9V9T5_DROME (48-723): 0: 627: 36.55		MCCB_DROME (6-530): 0: 582: 29.61
+	Hs
		425799 PCCA_HUMAN (1-724): 0: 741: 89.15		ACACA_HUMAN (119-500): 3.03e-146: 466: 21.38
+	Hs
		1094267 ACACA_HUMAN (4-724): 0: 627: 24.87		MCCB_HUMAN (14-531): 0: 577: 29.87
+	Hs
		1094241 MCCA_HUMAN (1-724): 0: 674: 36.64		ACACA_HUMAN (119-500): 3.03e-146: 466: 21.38
+	Pa
		1439899 Q9I299_PSEAE (52-724): 0: 567: 40.06		Q9I297_PSEAE (16-530): 0: 558: 28.94
+	Hs
		144206 ACACB_HUMAN (3-724): 0: 631: 24.72		ACACB_HUMAN (119-498): 1.01e-149: 476: 22.43
+	Hs
		144259 ACACB_HUMAN (3-724): 0: 631: 24.72		ACACA_HUMAN (119-500): 3.03e-146: 466: 21.38
+	Hs
		1094166 ACACA_HUMAN (4-724): 0: 627: 24.87		ACACA_HUMAN (119-500): 3.03e-146: 466: 21.38
+	Sc
		746522 HFA1_YEAST (15-723): 0: 583: 27.56		ACAC_YEAST (119-498): 2.49e-129: 418: 19.86
+	Sc
		1028015 ACAC_YEAST (14-723): 3.31e-180: 568: 25.96		ACAC_YEAST (119-498): 2.49e-129: 418: 19.86
+	Hs
		425873 PYC_HUMAN (615-724): 1.72e-10: 66.7: 30.91		PCCB_HUMAN (1-541): 0: 725: 92.42
+	Ec
		497152 ACCC_ECOLI (58-504): 2.58e-168: 492: 47.77		ACCD_ECOLI (1-243): 1.85e-55: 190: 22.84
+	Nv
		1259978 Q729X1_NITV2 (60-486): 4.21e-156: 462: 31.75		Q729X2_NITV2 (63-244): 1.26e-35: 143: 20.83