Protein: PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)

Gene: PCCB
Organism: Homo sapiens
Interactions: 133
UniProt ID: P05166

Gene Ontology (top 5):
GO:0004658 - propionyl-CoA carboxylase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

425760

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

5

18

Small-scale

0.932

High

425950

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

2

19

High-throughput

0.789

High

425873

PYC
Pyruvate carboxylase, mitochondrial

1

19

High-throughput

0.618

High

425904

ACACA
Acetyl-CoA carboxylase 1

1

19

High-throughput

0.618

High

425961

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

16

High-throughput

0.618

High

240482

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

425903

ACTN3
Alpha-actinin-3

2

0

High-throughput

0.580

High

425874

TPR
Nucleoprotein TPR

2

2

High-throughput

0.549

High

187249

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

2

High-throughput

0.536

High

275233

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.536

High

288213

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

1

High-throughput

0.536

High

425871

IFIT1
Antiviral innate immune response effector IFIT1

1

4

High-throughput

0.536

High

425883

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

3

High-throughput

0.536

High

425890

WHR1
Winged helix repair factor 1

1

1

High-throughput

0.536

High

425901

CDK17
Cyclin-dependent kinase 17

1

3

High-throughput

0.536

High

425906

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.536

High

425918

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

1

High-throughput

0.536

High

425924

TLK2
Serine/threonine-protein kinase tousled-like 2

1

3

High-throughput

0.536

High

425945

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

1

High-throughput

0.536

High

425947

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.536

High

425959

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.536

High

425965

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

1

5

High-throughput

0.536

High

425970

NPS3A
Protein NipSnap homolog 3A

1

1

High-throughput

0.536

High

425891

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.518

High

425878

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

425909

SYLM
Leucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

425944

P5CR2
Pyrroline-5-carboxylate reductase 2

1

0

High-throughput

0.513

High

425946

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

425952

HDHD3
Haloacid dehalogenase-like hydrolase domain-containing protein 3

1

0

High-throughput

0.513

High

425953

DHRS4
Dehydrogenase/reductase SDR family member 4

1

0

High-throughput

0.513

High

425955

COMD5
COMM domain-containing protein 5

1

0

High-throughput

0.513

High

425968

RM27
Large ribosomal subunit protein bL27m

1

0

High-throughput

0.513

High

425972

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

425973

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

425979

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

425980

PUS1
Pseudouridylate synthase 1 homolog

1

0

High-throughput

0.513

High

425879

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

3

High-throughput

0.489

High

425928

PAF1
RNA polymerase II-associated factor 1 homolog

1

2

High-throughput

0.489

High

125144

LEG9
Galectin-9

1

2

High-throughput

0.479

High

131660

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

Small-scale

0.479

High

176120

PER2
Period circadian protein homolog 2

1

3

Small-scale

0.479

High

285033

EED
Polycomb protein EED

1

18

High-throughput

0.479

High

315009

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

323093

TRI37
E3 ubiquitin-protein ligase TRIM37

1

4

High-throughput

0.479

High

345253

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

413007

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

425872

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.479

High

425875

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.479

High

425876

ARF4
ADP-ribosylation factor 4

1

3

High-throughput

0.479

High

425880

PML
Protein PML

1

3

High-throughput

0.479

High

425885

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

425886

EPS15
Epidermal growth factor receptor substrate 15

1

1

High-throughput

0.479

High

425887

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

16

High-throughput

0.479

High

425893

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

Small-scale

0.479

High

425894

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

1

Small-scale

0.479

High

425896

RBX1
E3 ubiquitin-protein ligase RBX1

1

3

High-throughput

0.479

High

425897

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

16

High-throughput

0.479

High

425905

HDAC1
Histone deacetylase 1

1

5

High-throughput

0.479

High

425910

RBBP7
Histone-binding protein RBBP7

1

18

High-throughput

0.479

High

425911

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

425914

DCAF6
DDB1- and CUL4-associated factor 6

1

20

High-throughput

0.479

High

425916

DCA12
DDB1- and CUL4-associated factor 12

1

2

High-throughput

0.479

High

425917

A16L1
Autophagy-related protein 16-1

1

19

High-throughput

0.479

High

425919

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

425923

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

425927

WDTC1
WD and tetratricopeptide repeats protein 1

1

20

High-throughput

0.479

High

425930

ARL10
ADP-ribosylation factor-like protein 10

1

6

High-throughput

0.479

High

425931

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

425932

COP1
E3 ubiquitin-protein ligase COP1

1

20

High-throughput

0.479

High

425937

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

1

High-throughput

0.479

High

425939

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

425941

FBXW5
F-box/WD repeat-containing protein 5

1

2

High-throughput

0.479

High

425948

BICD1
Protein bicaudal D homolog 1

1

2

High-throughput

0.479

High

425951

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

425954

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

1

15

High-throughput

0.479

High

425962

DCA13
DDB1- and CUL4-associated factor 13

1

15

High-throughput

0.479

High

425966

WSB2
WD repeat and SOCS box-containing protein 2

1

18

High-throughput

0.479

High

425971

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

425975

DCTN4
Dynactin subunit 4

1

1

High-throughput

0.479

High

425978

FBW1A
F-box/WD repeat-containing protein 1A

1

15

High-throughput

0.479

High

425907

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.458

High

425940

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.458

High

425958

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

High-throughput

0.458

High

425877

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

High-throughput

0.445

High

425900

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

High-throughput

0.445

High

425899

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.438

High

105117

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

246392

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.437

High

318572

RHBT1
Rho-related BTB domain-containing protein 1

1

4

High-throughput

0.437

High

352840

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.437

High

370915

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

425882

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

425884

TRI23
E3 ubiquitin-protein ligase TRIM23

1

7

High-throughput

0.437

High

425889

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.437

High

425895

WDR5
WD repeat-containing protein 5

1

16

High-throughput

0.437

High

425898

DYLT1
Dynein light chain Tctex-type 1

1

1

High-throughput

0.437

High

425902

TLE2
Transducin-like enhancer protein 2

1

17

High-throughput

0.437

High

425912

ISX
Intestine-specific homeobox

1

2

High-throughput

0.437

High

425913

SMU1
WD40 repeat-containing protein SMU1

1

20

High-throughput

0.437

High

425915

DCA10
DDB1- and CUL4-associated factor 10

1

20

High-throughput

0.437

High

425920

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

425921

DET1
DET1 homolog

1

3

High-throughput

0.437

High

425922

WDR53
WD repeat-containing protein 53

1

16

High-throughput

0.437

High

425925

HOOK3
Protein Hook homolog 3

1

5

High-throughput

0.437

High

425934

POC1B
POC1 centriolar protein homolog B

1

18

High-throughput

0.437

High

425935

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.437

High

425936

PHIP
PH-interacting protein

1

16

High-throughput

0.437

High

425938

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.437

High

425942

PF21A
PHD finger protein 21A

1

3

High-throughput

0.437

High

425957

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.437

High

425960

WDR76
WD repeat-containing protein 76

1

20

High-throughput

0.437

High

425963

NLE1
Notchless protein homolog 1

1

11

High-throughput

0.437

High

425964

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

2

High-throughput

0.437

High

425967

VSX1
Visual system homeobox 1

1

2

High-throughput

0.437

High

425974

HOOK1
Protein Hook homolog 1

1

5

High-throughput

0.437

High

425976

RCOR1
REST corepressor 1

1

3

High-throughput

0.437

High

425981

ARL5A
ADP-ribosylation factor-like protein 5A

1

8

High-throughput

0.437

High

425933

FA81A
Protein FAM81A

2

0

High-throughput

0.313

High

66920

AQ12B
Putative aquaporin-12B

1

0

High-throughput

0.279

Low

286517

SG2A1
Mammaglobin-B

1

0

High-throughput

0.279

Low

425881

LCN1
Lipocalin-1

1

0

High-throughput

0.279

Low

425926

AMZ2
Archaemetzincin-2

1

0

High-throughput

0.279

Low

425943

TRI43
Tripartite motif-containing protein 43

1

0

High-throughput

0.279

Low

425949

O52B2
Olfactory receptor 52B2

1

0

High-throughput

0.279

Low

425956

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low

425888

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.261

Low

425969

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.251

Low

168804

PLD2
Phospholipase D2

1

0

High-throughput

0.249

Low

289104

PRDM1
PR domain zinc finger protein 1

1

0

High-throughput

0.249

Low

425908

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

425929

PLD5
Inactive phospholipase D5

1

0

High-throughput

0.249

Low

425977

LHX6
LIM/homeobox protein Lhx6

1

0

High-throughput

0.249

Low

425892

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025