HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: CKAP5 (Q14008)
Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG)
Gene: CKAP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26496610, 36042349
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0032991 - protein-containing complex and 1 others more... GO:0045296 - cadherin binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 2032
+	Hs
		504058 HSP7C_HUMAN (26-637): 0: 916: 66.02		CKAP5_HUMAN (1-2032): 0: 1608: 100.00
+	Hs
		871564 HSP72_HUMAN (25-636): 0: 905: 64.51		CKAP5_HUMAN (1-2032): 0: 1608: 100.00
+	Hs
		254543 BIP_HUMAN (19-654): 0: 914: 100.00		CLAP2_HUMAN (1086-1611): 1.06e-43: 177: 13.65
+	Hs
		504307 HSP7C_HUMAN (26-637): 0: 916: 66.02		CLAP1_HUMAN (366-1077): 2e-13: 78.6: 8.85
+	Sc
		560713 BIP_YEAST (22-638): 0: 798: 68.82		STU2_YEAST (651-1235): 8.38e-49: 191: 14.54
+	Hs
		127172 BIP_HUMAN (19-654): 0: 914: 100.00		IPO5_HUMAN (14-503): 9.94e-12: 72.8: 11.37
+	Hs
		503511 HSP7C_HUMAN (26-637): 0: 916: 66.02		2AAB_HUMAN (656-1045): 1.6e-10: 68.4: 14.18
+	Hs
		503510 HSP7C_HUMAN (26-637): 0: 916: 66.02		2AAA_HUMAN (656-1045): 2.01e-10: 68: 13.11