HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UB2G2 (P60604)
Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2)
Gene: UBE2G2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	27182664, 32296183, 21098018, 16214370, unassigned1304
Identification Methods	proximity labelling technology, two hybrid, x-ray crystallography, pull down, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	UQ_con~ubiquitin
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 165
+	Hs
		508868 UBC_HUMAN (1-685): 0: 857: 100.00		UB2D4_HUMAN (4-164): 1.27e-73: 218: 36.03
+	Hs
		507701 UBC_HUMAN (1-685): 0: 857: 100.00		UB2D1_HUMAN (4-164): 2.21e-72: 215: 36.03
+	Hs
		507793 UBC_HUMAN (1-685): 0: 857: 100.00		UB2D2_HUMAN (4-164): 2.47e-72: 215: 36.03
+	Hs
		507755 UBC_HUMAN (1-685): 0: 857: 100.00		UB2D3_HUMAN (4-164): 4.3e-71: 212: 34.78
+	Hs
		507779 UBC_HUMAN (1-685): 0: 857: 100.00		UB2G1_HUMAN (4-164): 3.81e-68: 205: 50.00
+	Hs
		507680 UBC_HUMAN (1-685): 0: 857: 100.00		UBE2A_HUMAN (1-162): 1.27e-66: 201: 38.89
+	Hs
		508183 UBC_HUMAN (1-685): 0: 857: 100.00		UB2R2_HUMAN (4-158): 9.25e-45: 149: 50.00
+	Hs
		507678 UBC_HUMAN (1-685): 0: 857: 100.00		UB2R1_HUMAN (4-159): 1.55e-43: 145: 49.08
+	Rn
		92896 UBC_RAT (1-637): 0: 779: 98.90		UB2D1_RAT (4-164): 2.21e-72: 215: 36.03
+	Hs
		507805 UBC_HUMAN (1-685): 0: 857: 100.00		UBE2B_HUMAN (1-162): 1.26e-35: 122: 38.89
+	Xl
		982387 Q7SY79_XENLA (77-685): 0: 752: 99.84		UB2D2_XENLA (4-164): 2.47e-72: 215: 36.03
+	Dm
		683066 Q9W418_DROME (229-685): 0: 567: 99.78		UBCD1_DROME (4-164): 8.05e-72: 214: 34.78
+	Sc
		509374 UBI4P_YEAST (381-685): 4.09e-126: 380: 95.74		UBC4_YEAST (1-163): 1.67e-70: 211: 31.90
+	Sc
		509687 UBI4P_YEAST (381-685): 4.09e-126: 380: 95.74		UBC7_YEAST (1-165): 5.62e-69: 207: 62.42
+	Sc
		509369 UBI4P_YEAST (381-685): 4.09e-126: 380: 95.74		UBC3_YEAST (4-162): 3.32e-37: 130: 44.79
+	Sc
		438513 UBI4P_YEAST (381-685): 4.09e-126: 380: 95.74		UBC2_YEAST (1-162): 1.08e-33: 118: 37.65
+	At
		762746 UBQ3_ARATH (457-685): 4e-89: 282: 95.63		UBC8_ARATH (4-164): 1.43e-72: 216: 36.03
+	At
		762762 UBQ3_ARATH (457-685): 4e-89: 282: 95.63		UBC9_ARATH (4-164): 3.95e-72: 215: 36.03
+	At
		762777 UBQ3_ARATH (457-685): 4e-89: 282: 95.63		UBC10_ARATH (4-164): 6.12e-72: 214: 35.40
+	At
		683037 UBQ3_ARATH (457-685): 4e-89: 282: 95.63		UBC1_ARATH (1-162): 3.17e-35: 121: 38.27