HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: TRI25 (Q14258)
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)
Gene: TRIM25

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	27425606
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_UBOX
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 630
+	Hs
		186499 UBC_HUMAN (1-685): 0: 857: 100.00		TRI18_HUMAN (4-629): 3.86e-113: 355: 22.47
+	Hs
		508680 UBC_HUMAN (1-685): 0: 857: 100.00		TRI36_HUMAN (4-621): 5.62e-77: 261: 15.11
+	Hs
		507515 UBC_HUMAN (1-685): 0: 857: 100.00		RO52_HUMAN (2-263): 6.24e-30: 125: 18.32
+	Hs
		508670 UBC_HUMAN (1-685): 0: 857: 100.00		TRI39_HUMAN (4-490): 1.42e-29: 124: 15.23
+	Hs
		508576 UBC_HUMAN (1-685): 0: 857: 100.00		TRIM5_HUMAN (2-246): 3.41e-29: 123: 17.74
+	Hs
		507484 UBC_HUMAN (1-685): 0: 857: 100.00		TRI27_HUMAN (7-471): 1.69e-28: 121: 13.46
+	Hs
		508900 UBC_HUMAN (1-685): 0: 857: 100.00		TRI17_HUMAN (117-335): 7.84e-09: 60.5: 16.74
+	Xl
		1274149 Q7SY79_XENLA (77-685): 0: 752: 99.84		NF7B_XENLA (1-287): 1.37e-28: 122: 18.06
+	Hs
		987022 RS27A_HUMAN (609-684): 7.26e-41: 148: 100.00		TRI25_HUMAN (1-630): 3.45e-145: 436: 100.00
+	Mm
		508944 UBB_MOUSE (457-685): 1.43e-90: 286: 99.56		TRI29_MOUSE (96-348): 4.87e-59: 209: 28.30
+	Mm
		508938 UBB_MOUSE (457-685): 1.43e-90: 286: 99.56		RO52_MOUSE (4-264): 5.24e-29: 122: 18.39
+	Hs
		507381 UBB_HUMAN (1-77): 1.15e-26: 110: 98.70		TRI36_HUMAN (4-621): 5.62e-77: 261: 15.11
+	Mm
		509100 UBC_MOUSE (1-108): 2.12e-30: 129: 90.74		RO52_MOUSE (4-264): 5.24e-29: 122: 18.39
+	Hs
		507358 UBB_HUMAN (1-77): 1.15e-26: 110: 98.70		TRIM5_HUMAN (2-246): 3.41e-29: 123: 17.74
+	Hs
		507312 UBB_HUMAN (1-77): 1.15e-26: 110: 98.70		TRI11_HUMAN (6-273): 2.4e-28: 120: 20.15