HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: NKX31 (Q99801)
Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A)
Gene: NKX3-1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	23557481, 17234752, 27339988
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, confocal microscopy, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 234
+	Hs
		508387 TOP1_HUMAN (1-765): 0: 932: 100.00		NKX21_HUMAN (120-182): 2.75e-16: 78.6: 63.49
+	Hs
		679119 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		TLX1_HUMAN (54-221): 5.02e-36: 131: 30.18
+	Hs
		211883 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		TLX3_HUMAN (112-215): 4.85e-31: 117: 40.00
+	Hs
		213344 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		TLX2_HUMAN (114-196): 1.57e-12: 67: 48.19