HitPredict

Interactor 1: NT2NC (P0DPK4)
Notch homolog 2 N-terminal-like protein C
Gene: NOTCH2NLC

Interactor 2: NECT2 (Q92692)
Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)
Gene: NECTIN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.594

Property	Details
Experiments	unassigned1304
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EGF~V-set
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 293 Hs			1 538
+	Hs
		516959 NT2NC_HUMAN (1-293): 8.11e-50: 168: 100.00		PVR_HUMAN (25-423): 4.78e-59: 203: 43.92
+	Hs
		1277339 NT2NA_HUMAN (22-229): 1.44e-15: 76.2: 30.70		NECT2_HUMAN (1-538): 2.84e-91: 291: 100.00
+	Hs
		517127 NT2NC_HUMAN (1-293): 8.11e-50: 168: 100.00		NTRI_HUMAN (20-360): 1.54e-54: 189: 15.58
+	Hs
		517119 NT2NC_HUMAN (1-293): 8.11e-50: 168: 100.00		NECT3_HUMAN (30-510): 3.44e-52: 188: 20.54
+	Hs
		580793 NT2NA_HUMAN (22-229): 1.44e-15: 76.2: 30.70		PVR_HUMAN (25-423): 4.78e-59: 203: 43.92
+	Hs
		1277433 NT2NA_HUMAN (22-229): 1.44e-15: 76.2: 30.70		NTRI_HUMAN (20-360): 1.54e-54: 189: 15.58
+	Hs
		1277420 NT2NA_HUMAN (22-229): 1.44e-15: 76.2: 30.70		NECT3_HUMAN (30-510): 3.44e-52: 188: 20.54
+	Hs
		317597 SLIT2_HUMAN (46-167): 1.35e-10: 63.9: 25.81		ROBO1_HUMAN (37-532): 4.85e-54: 199: 12.60
+	Ce
		109601 SLIT1_CAEEL (202-281): 5.19e-12: 68.1: 25.93		SAX3_CAEEL (33-445): 2.24e-49: 185: 13.51
+	Hs
		517001 NT2NC_HUMAN (1-293): 8.11e-50: 168: 100.00		PTK7_HUMAN (263-483): 1.84e-13: 75.5: 15.45
+	Dm
		233627 SLIT_DROME (11-123): 2.86e-12: 68.9: 23.58		O44924_DROME (29-469): 3.76e-45: 172: 13.33
+	Dm
		663803 SLIT_DROME (11-123): 2.86e-12: 68.9: 23.58		Q9W213_DROME (29-469): 7.84e-45: 172: 13.55
+	Hs
		1047673 NOTC2_HUMAN (6-246): 3.47e-10: 62.8: 21.52		PXDN_HUMAN (245-533): 2.69e-43: 167: 12.33
+	Dm
		663798 SLIT_DROME (11-123): 2.86e-12: 68.9: 23.58		Q9GPP7_DROME (38-486): 6.01e-41: 160: 11.65
+	Dm
		663802 SLIT_DROME (11-123): 2.86e-12: 68.9: 23.58		Q9VQ08_DROME (29-470): 5.97e-35: 142: 12.19
+	Dm
		663797 SLIT_DROME (11-123): 2.86e-12: 68.9: 23.58		Q9GPP6_DROME (24-365): 7.73e-17: 86.3: 10.75
+	Dm
		663801 SLIT_DROME (11-123): 2.86e-12: 68.9: 23.58		Q9VPZ7_DROME (24-365): 7.53e-17: 86.3: 10.75
+	Hs
		1101745 NT2NA_HUMAN (22-229): 1.44e-15: 76.2: 30.70		PTK7_HUMAN (263-483): 1.84e-13: 75.5: 15.45
+	Mm
		1190257 TEN4_MOUSE (2-107): 1.32e-09: 60.9: 13.87		PTK7_MOUSE (263-483): 8e-14: 76.7: 16.31
+	Dm
		663796 SLIT_DROME (11-123): 2.86e-12: 68.9: 23.58		Q5U176_DROME (382-528): 3.71e-11: 68.2: 10.07