HitPredict

Interactor 1: FCG2A (P12318)
Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32)
Gene: FCGR2A

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0032760 - positive regulation of tumor necrosis factor production
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 593
+	Hs
		986005 FCGRB_HUMAN (19-277): 6.97e-60: 194: 35.00		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		986016 FCRL3_HUMAN (22-311): 1.52e-27: 114: 17.65		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Mm
		682308 CEAM1_MOUSE (30-302): 1.62e-20: 93.8: 16.21		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		985950 PTK7_HUMAN (124-313): 1.3e-18: 88.3: 10.68		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		590601 CD22_HUMAN (31-309): 1.51e-30: 123: 16.61		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		685206 FCG2B_HUMAN (113-315): 1.08e-12: 69.4: 16.02		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		665941 FCRL3_HUMAN (22-311): 1.52e-27: 114: 17.65		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		532367 CEAM1_HUMAN (86-266): 2.45e-10: 63: 14.21		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Mm
		665992 FCRL5_MOUSE (22-294): 3.17e-27: 113: 15.72		PTN6_MOUSE (6-583): 0: 530: 55.94
+	Mm
		665976 CD22_MOUSE (28-290): 2.28e-25: 108: 13.25		PTN6_MOUSE (6-583): 0: 530: 55.94
+	Hs
		665883 PTK7_HUMAN (124-313): 1.3e-18: 88.3: 10.68		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		665804 FCG2B_HUMAN (113-315): 1.08e-12: 69.4: 16.02		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		532361 CEAM1_HUMAN (86-266): 2.45e-10: 63: 14.21		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		685236 CEAM8_HUMAN (86-216): 2.89e-09: 59.5: 16.08		PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76
+	Hs
		441175 CD22_HUMAN (31-309): 1.51e-30: 123: 16.61		PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29
+	Hs
		1069952 PXDN_HUMAN (207-292): 1.12e-09: 61.3: 8.14		PTPRK_HUMAN (36-524): 5.17e-72: 254: 18.94
+	Hs
		685244 CEAM8_HUMAN (86-216): 2.89e-09: 59.5: 16.08		PTPRK_HUMAN (36-524): 5.17e-72: 254: 18.94