Interactor 1: BMP2 (P12643)
Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)
Gene: BMP2

Interactor 2: RGMC (Q6ZVN8)
Hemojuvelin (Hemochromatosis type 2 protein) (Hemojuvelin BMP coreceptor) (RGM domain family member C)
Gene: HJV

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 1.00 0.812

The method score is based on:

Property Details
Experiments 25938661, 18335997
Identification Methods x-ray crystallography, surface plasmon resonance
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains RGM_C~TGF_beta, RGM_N~TGF_beta
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005102 - signaling receptor binding
GO:0005615 - extracellular space
GO:0006366 - transcription by RNA polymerase II
GO:0009986 - cell surface
and 4 others

more...

Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 396
Hs

1 426
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024