Interactor 1: SKI (P12755)
Ski oncogene (Proto-oncogene c-Ski)
Gene: SKI
Interactor 2: SMAD4 (Q13485)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
Gene: SMAD4
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.988 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 17469184, 25670202, 28468752, 12857746, 12419246, 19032343, 12732634, 14699069, 20959473, 14525983, 12764135, 25609649, 12874272, 10531062, 31932471, 33961781, 15761153, 15231748, 26977879 |
| Identification Methods | affinity chromatography technology, x-ray crystallography, pull down, two hybrid, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation, coimmunoprecipitation |
| Interaction Type | physical association, association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | MH2~c-SKI_SMAD_bind |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0005654 - nucleoplasm and 6 others more... |
| Homologous interactions | 16 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
