HitPredict

Interactor 1: PTPRF (P10586)
Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR)
Gene: PTPRF

Interactor 2: PCD12 (Q9NPG4)
Protocadherin-12 (Vascular cadherin-2) (Vascular endothelial cadherin-2) (VE-cad-2) (VE-cadherin-2) [Cleaved into: Protocadherin-12, secreted form]
Gene: PCDH12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1907 Hs			1 1184
+	Hs
		1102760 PTPRS_HUMAN (1-1907): 0: 1569: 65.52		PCD12_HUMAN (26-1184): 0: 1264: 100.00
+	Hs
		522762 PTPRF_HUMAN (1-1907): 0: 1645: 100.00		PCDGD_HUMAN (137-1095): 2.2e-139: 447: 19.76
+	Hs
		1102776 PTPRS_HUMAN (1-1907): 0: 1569: 65.52		PCDGD_HUMAN (137-1095): 2.2e-139: 447: 19.76
+	Hs
		1102778 PTPRS_HUMAN (1-1907): 0: 1569: 65.52		PCDG6_HUMAN (250-1095): 9.66e-117: 387: 17.40
+	Hs
		658948 PTPRD_HUMAN (29-1907): 0: 1562: 69.67		PCDG6_HUMAN (250-1095): 9.66e-117: 387: 17.40
+	Hs
		1102775 PTPRS_HUMAN (1-1907): 0: 1569: 65.52		PCDGE_HUMAN (3-452): 2.4e-100: 342: 24.35
+	Hs
		1102777 PTPRS_HUMAN (1-1907): 0: 1569: 65.52		PCDG7_HUMAN (3-452): 2.59e-98: 336: 25.87
+	Hs
		658946 PTPRD_HUMAN (29-1907): 0: 1562: 69.67		PCDB6_HUMAN (250-896): 1.9e-101: 341: 22.22
+	Hs
		658945 PTPRD_HUMAN (29-1907): 0: 1562: 69.67		PCDGG_HUMAN (3-452): 5.97e-98: 335: 26.30
+	Hs
		522763 PTPRF_HUMAN (1-1907): 0: 1645: 100.00		PCDG5_HUMAN (364-948): 3.88e-62: 231: 17.60
+	Hs
		522743 PTPRF_HUMAN (1-1907): 0: 1645: 100.00		PCDBG_HUMAN (693-947): 1.98e-09: 64: 10.07
+	Hs
		658947 PTPRD_HUMAN (29-1907): 0: 1562: 69.67		PCDB1_HUMAN (120-558): 4.5e-33: 140: 27.82
+	Hs
		658936 PTPRD_HUMAN (29-1907): 0: 1562: 69.67		PCDBG_HUMAN (693-947): 1.98e-09: 64: 10.07
+	Hs
		659067 PTPRG_HUMAN (894-1904): 0: 737: 26.66		PCDGK_HUMAN (90-564): 1.37e-30: 132: 28.63
+	Hs
		1201830 SDK2_HUMAN (165-1102): 1.46e-112: 401: 20.04		PCDGD_HUMAN (137-1095): 2.2e-139: 447: 19.76
+	Hs
		1366857 PTPRU_HUMAN (202-746): 3.05e-20: 100: 14.36		PCDGD_HUMAN (137-1095): 2.2e-139: 447: 19.76
+	Hs
		1144690 PTPRK_HUMAN (113-666): 1.87e-16: 88.1: 15.27		PCDGD_HUMAN (137-1095): 2.2e-139: 447: 19.76
+	Hs
		1366848 PTPRU_HUMAN (202-746): 3.05e-20: 100: 14.36		PCDGG_HUMAN (3-452): 5.97e-98: 335: 26.30
+	Hs
		1144687 PTPRK_HUMAN (113-666): 1.87e-16: 88.1: 15.27		PCDGG_HUMAN (3-452): 5.97e-98: 335: 26.30
+	Hs
		1366855 PTPRU_HUMAN (202-746): 3.05e-20: 100: 14.36		PCDB3_HUMAN (287-832): 3.7e-83: 290: 21.03