HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.714

Property	Details
Experiments	36931259, 32812023, 35063084, 26269332, 28575131
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, comigration in non denaturing gel electrophoresis, anti bait coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048167 - regulation of synaptic plasticity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 247
+	Hs
		529515 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		1433E_HUMAN (1-244): 2.03e-141: 398: 63.53
+	Hs
		529677 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		1433F_HUMAN (1-246): 2.51e-135: 382: 86.99
+	Rn
		620031 TAU_RAT (1-758): 3.21e-76: 263: 72.11		1433E_RAT (1-244): 2.03e-141: 398: 63.53
+	Rn
		98722 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		1433E_RAT (1-244): 2.03e-141: 398: 63.53
+	Rn
		620030 TAU_RAT (1-758): 3.21e-76: 263: 72.11		1433G_RAT (1-247): 3.17e-139: 392: 100.00
+	Rn
		98721 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		1433G_RAT (1-247): 3.17e-139: 392: 100.00
+	Mm
		530753 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		1433E_MOUSE (1-244): 2.03e-141: 398: 63.53
+	Mm
		530751 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		1433G_MOUSE (1-247): 3.17e-139: 392: 100.00
+	Mm
		530783 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		1433F_MOUSE (1-246): 1.52e-136: 385: 86.99
+	Hs
		529193 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		1433B_HUMAN (2-247): 1.92e-109: 317: 75.40
+	Hs
		529573 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		1433Z_HUMAN (2-245): 2.4e-108: 314: 74.59
+	Hs
		529134 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		1433T_HUMAN (2-245): 5.55e-105: 305: 70.33
+	Hs
		529194 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		1433S_HUMAN (2-245): 1.87e-98: 289: 65.16
+	Rn
		620040 TAU_RAT (1-758): 3.21e-76: 263: 72.11		1433Z_RAT (2-245): 8.5e-109: 315: 74.59
+	Rn
		98731 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		1433Z_RAT (2-245): 8.5e-109: 315: 74.59
+	Rn
		620043 TAU_RAT (1-758): 3.21e-76: 263: 72.11		1433T_RAT (2-245): 3.01e-105: 306: 70.73
+	Rn
		98734 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		1433T_RAT (2-245): 3.01e-105: 306: 70.73
+	Mm
		530775 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		1433Z_MOUSE (2-245): 8.5e-109: 315: 74.59
+	Mm
		530905 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		1433B_MOUSE (2-247): 8.61e-109: 315: 75.81
+	Mm
		267030 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		1433S_MOUSE (2-236): 1.39e-95: 281: 65.96