HitPredict

Interactor 1: SRS10 (O75494)
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: SRSF10

Interactor 2: DOT1L (Q8TEK3)
Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)
Gene: DOT1L

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35850772
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 262 Hs			1 1537
+	Hs
		952054 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		964034 SRSF2_HUMAN (4-90): 1.89e-24: 99.3: 45.65		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		1031399 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		516603 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		DOT1L_HUMAN (1-1537): 0: 2441: 100.00