HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.763

Property	Details
Experiments	19138662, 19647741, 27548710, 23962087, 17317006, 10840038, 15650334, 29659825, 12551948, 35063084, 26269332, 28575131
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, molecular sieving, comigration in non denaturing gel electrophoresis, anti bait coimmunoprecipitation, cross-linking study, biochemical, coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 245
+	Hs
		529515 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		1433E_HUMAN (2-241): 9.95e-144: 403: 68.18
+	Hs
		529134 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		1433T_HUMAN (1-245): 2.61e-140: 395: 79.59
+	Hs
		529193 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		1433B_HUMAN (1-242): 9.05e-140: 393: 87.60
+	Rn
		620040 TAU_RAT (1-758): 3.21e-76: 263: 72.11		1433Z_RAT (1-245): 3.49e-145: 407: 99.59
+	Rn
		98731 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		1433Z_RAT (1-245): 3.49e-145: 407: 99.59
+	Rn
		620031 TAU_RAT (1-758): 3.21e-76: 263: 72.11		1433E_RAT (2-241): 9.95e-144: 403: 68.18
+	Rn
		98722 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		1433E_RAT (2-241): 9.95e-144: 403: 68.18
+	Mm
		530775 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		1433Z_MOUSE (1-245): 3.49e-145: 407: 99.59
+	Rn
		620043 TAU_RAT (1-758): 3.21e-76: 263: 72.11		1433T_RAT (1-245): 9.02e-140: 393: 79.18
+	Rn
		98734 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		1433T_RAT (1-245): 9.02e-140: 393: 79.18
+	Mm
		530753 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		1433E_MOUSE (2-241): 9.95e-144: 403: 68.18
+	Hs
		529505 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		1433G_HUMAN (1-240): 2.38e-108: 314: 74.59
+	Mm
		530905 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		1433B_MOUSE (1-242): 3.79e-128: 364: 87.19
+	Hs
		529677 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		1433F_HUMAN (2-240): 1.27e-107: 312: 74.49
+	Hs
		529194 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		1433S_HUMAN (1-237): 8.31e-104: 302: 71.97
+	Rn
		620030 TAU_RAT (1-758): 3.21e-76: 263: 72.11		1433G_RAT (1-240): 2.38e-108: 314: 74.59
+	Rn
		98721 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		1433G_RAT (1-240): 2.38e-108: 314: 74.59
+	Mm
		530751 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		1433G_MOUSE (1-240): 2.38e-108: 314: 74.59
+	Mm
		530783 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		1433F_MOUSE (2-240): 1.16e-107: 312: 74.07
+	Mm
		267030 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		1433S_MOUSE (1-232): 7.95e-104: 302: 73.08