HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	26618866, 29924966
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0031901 - early endosome membrane and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 903
+	Hs
		125126 CFTR_HUMAN (1-1480): 0: 1031: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		529592 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		528744 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		529347 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88