HitPredict - High confidence protein-protein interactions

Interactor 1: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Interactor 2: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	12634056, 31980649, 31839598, 20133847, 31515488
Identification Methods	affinity chromatography technology, two hybrid, cross-linking study, bimolecular fluorescence complementation, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	cNMP_binding~cNMP_binding, RIIa~RIIa
Common GO terms	GO:0001707 - mesoderm formation GO:0004862 - cAMP-dependent protein kinase inhibitor activity GO:0005737 - cytoplasm GO:0005771 - multivesicular body GO:0005813 - centrosome and 25 others more... GO:0005829 - cytosol GO:0005952 - cAMP-dependent protein kinase complex GO:0006357 - regulation of transcription by RNA polymerase II GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0008603 - cAMP-dependent protein kinase regulator activity GO:0010629 - negative regulation of gene expression GO:0016020 - membrane GO:0019904 - protein domain specific binding GO:0030552 - cAMP binding GO:0031588 - nucleotide-activated protein kinase complex GO:0031594 - neuromuscular junction GO:0031625 - ubiquitin protein ligase binding GO:0032024 - positive regulation of insulin secretion GO:0032991 - protein-containing complex GO:0034236 - protein kinase A catalytic subunit binding GO:0035556 - intracellular signal transduction GO:0044853 - plasma membrane raft GO:0045214 - sarcomere organization GO:0046007 - negative regulation of activated T cell proliferation GO:0060038 - cardiac muscle cell proliferation GO:0071377 - cellular response to glucagon stimulus GO:0097546 - ciliary base GO:0098978 - glutamatergic synapse GO:0120212 - sperm head-tail coupling apparatus GO:0141162 - negative regulation of cAMP/PKA signal transduction
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1	381
Hs

1	381

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Last updated: 11Aug2025