Protein: PLPL6
Patatin-like phospholipase domain-containing protein 6 (EC 3.1.1.5) (Neuropathy target esterase)

Gene: PLPL6, PNPLA6
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q8IY17

Gene Ontology (top 5):
GO:0004622 - phosphatidylcholine lysophospholipase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1313223

KCNS3
Delayed-rectifier potassium channel regulatory subunit KCNS3

2

0

High-throughput

0.770

High

1104438

ILK
Scaffold protein ILK

1

2

High-throughput

0.691

High

1110495

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

3

High-throughput

0.691

High

1256798

PLPL7
Patatin-like phospholipase domain-containing protein 7

1

18

High-throughput

0.691

High

946568

EVA1C
Protein eva-1 homolog C

3

1

High-throughput

0.667

High

1313211

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

3

0

High-throughput

0.638

High

749788

CADH5
Cadherin-5

2

6

High-throughput

0.628

High

1313231

PCDBG
Protocadherin beta-16

2

6

High-throughput

0.628

High

1313245

RPKL1
Ribosomal protein S6 kinase-like 1

1

20

High-throughput

0.618

High

762022

GRK5
G protein-coupled receptor kinase 5

1

20

High-throughput

0.618

High

1288319

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

0

High-throughput

0.602

High

1313219

MRAP2
Melanocortin-2 receptor accessory protein 2

2

0

High-throughput

0.602

High

396472

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

627543

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

2

3

High-throughput

0.558

High

1186113

ANR55
Ankyrin repeat domain-containing protein 55

1

1

High-throughput

0.553

High

270154

LRP3
Low-density lipoprotein receptor-related protein 3

1

1

High-throughput

0.536

High

380453

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

3

High-throughput

0.536

High

698862

CALX
Calnexin

1

1

High-throughput

0.536

High

724492

GDIA
Rab GDP dissociation inhibitor alpha

1

1

High-throughput

0.536

High

911937

JAK3
Tyrosine-protein kinase JAK3

1

4

High-throughput

0.536

High

1111602

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.536

High

1126239

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

4

High-throughput

0.536

High

1216380

FAXC
Failed axon connections homolog

1

1

High-throughput

0.536

High

1306875

INLR1
Interferon lambda receptor 1

1

2

High-throughput

0.536

High

1313232

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.536

High

1313238

PCDB6
Protocadherin beta-6

1

6

High-throughput

0.536

High

1313239

PCDB3
Protocadherin beta-3

1

6

High-throughput

0.536

High

1313240

PCDBB
Protocadherin beta-11

1

5

High-throughput

0.536

High

656181

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

3

High-throughput

0.515

High

1215250

SL9C2
Sodium/hydrogen exchanger 11

1

6

High-throughput

0.514

High

181369

PGRC2
Membrane-associated progesterone receptor component 2

1

0

High-throughput

0.513

High

1060105

BAX
Apoptosis regulator BAX

1

0

High-throughput

0.513

High

1203717

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

1249617

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.513

High

1310213

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1313206

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.513

High

1313227

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

508258

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.501

High

956932

CXCR4
C-X-C chemokine receptor type 4

1

1

High-throughput

0.489

High

1180929

HFE
Hereditary hemochromatosis protein

1

2

High-throughput

0.489

High

1313241

PCDGM
Protocadherin gamma-C5

1

3

High-throughput

0.489

High

1313242

PCDGL
Protocadherin gamma-C4

1

5

High-throughput

0.489

High

1313243

PCDGH
Protocadherin gamma-B5

1

6

High-throughput

0.489

High

242230

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

831038

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

884361

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

High-throughput

0.479

High

952946

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.479

High

962249

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

993238

ACTG
Actin, cytoplasmic 2

1

1

High-throughput

0.479

High

1045491

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

1113636

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1249000

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1308150

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

1313213

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1313220

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

1313228

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1313230

ANLN
Anillin

1

1

High-throughput

0.479

High

1313235

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

129242

MEN1
Menin

1

0

High-throughput

0.458

High

894888

EMD
Emerin

1

0

High-throughput

0.458

High

1161021

FSCN1
Fascin

1

0

High-throughput

0.458

High

1161320

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

1178240

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1313207

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1313215

FAF2
FAS-associated factor 2

1

0

High-throughput

0.458

High

1313216

GASP2
G-protein coupled receptor-associated sorting protein 2

1

0

High-throughput

0.458

High

1313229

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1313244

TX264
Testis-expressed protein 264

1

0

High-throughput

0.458

High

933526

S12A3
Solute carrier family 12 member 3

1

2

High-throughput

0.445

High

1133789

SL9A5
Sodium/hydrogen exchanger 5

1

6

High-throughput

0.445

High

1227028

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.445

High

1313214

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

2

High-throughput

0.445

High

1313222

SL9A7
Sodium/hydrogen exchanger 7

1

6

High-throughput

0.445

High

106239

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

136933

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

2

High-throughput

0.437

High

293988

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

342245

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.437

High

372525

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

412230

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

1254556

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1313212

ESR2
Estrogen receptor beta

1

6

High-throughput

0.437

High

166341

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.407

High

877692

SL9A3
Sodium/hydrogen exchanger 3

1

6

High-throughput

0.407

High

1197820

S39AC
Zinc transporter ZIP12

1

3

High-throughput

0.407

High

1230822

SL9A4
Sodium/hydrogen exchanger 4

1

6

High-throughput

0.407

High

1242850

S39A4
Zinc transporter ZIP4

1

3

High-throughput

0.407

High

1313204

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

1313224

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

1

High-throughput

0.407

High

1313226

S39A8
Metal cation symporter ZIP8

1

3

High-throughput

0.407

High

1313209

HAVR2
Hepatitis A virus cellular receptor 2

3

0

High-throughput

0.345

High

821740

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.328

High

1142502

PDCD1
Programmed cell death protein 1

2

0

High-throughput

0.328

High

1313218

TSN17
Tetraspanin-17

2

0

High-throughput

0.318

High

1313236

NGN3
Neurogenin-3

2

0

Small-scale

0.318

High

914448

EFNB2
Ephrin-B2

2

0

High-throughput

0.313

High

49793

CLRN2
Clarin-2

1

0

High-throughput

0.279

Low

260777

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.279

Low

292370

RA51D
DNA repair protein RAD51 homolog 4

1

0

High-throughput

0.279

Low

596502

CTLA4
Cytotoxic T-lymphocyte protein 4

1

0

High-throughput

0.279

Low

733016

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.279

Low

760470

SDC2
Syndecan-2

1

0

High-throughput

0.279

Low

1057559

ACHD
Acetylcholine receptor subunit delta

1

0

High-throughput

0.279

Low

1195444

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.279

Low

1313208

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.279

Low

1313217

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1313233

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1313237

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.279

Low

1313225

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low

377648

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1313210

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

1278607

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.232

Low

1313205

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

1313221

B3A4
Anion exchange protein 4

1

0

High-throughput

0.232

Low

1313234

CCG5
Voltage-dependent calcium channel gamma-5 subunit

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025