HitPredict

Interactor 1: GNAI1 (P10824)
Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI1

Interactor 2: RGS4 (P49799)
Regulator of G-protein signaling 4 (RGP4) (RGS4)
Gene: RGS4

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9108480
Identification Methods	x-ray crystallography
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 354 Rn			1 205
+	Hs
		890698 GNAI1_HUMAN (1-354): 0: 516: 99.72		RGS4_HUMAN (1-205): 1.49e-81: 243: 97.07
+	Hs
		193887 GNAI1_HUMAN (1-354): 0: 516: 99.72		RGS5_HUMAN (1-179): 8.39e-69: 209: 52.49
+	Hs
		475923 GNAI3_HUMAN (1-354): 0: 508: 94.07		RGS3_HUMAN (16-184): 1.75e-64: 216: 52.66
+	Hs
		192036 GNAI1_HUMAN (1-354): 0: 516: 99.72		RGS16_HUMAN (1-177): 4.68e-67: 206: 48.89
+	Hs
		193879 GNAI3_HUMAN (1-354): 0: 508: 94.07		RGS5_HUMAN (1-179): 8.39e-69: 209: 52.49
+	Hs
		303125 GNAI1_HUMAN (1-354): 0: 516: 99.72		RGS20_HUMAN (24-185): 1.39e-62: 200: 38.27
+	Hs
		192031 GNAI3_HUMAN (1-354): 0: 508: 94.07		RGS16_HUMAN (1-177): 4.68e-67: 206: 48.89
+	Hs
		475924 GNAI3_HUMAN (1-354): 0: 508: 94.07		RGS7_HUMAN (7-198): 1.09e-63: 206: 27.23
+	Hs
		989885 GNAI1_HUMAN (1-354): 0: 516: 99.72		RGS18_HUMAN (15-179): 1.32e-60: 191: 47.88
+	Hs
		890627 GNAI1_HUMAN (1-354): 0: 516: 99.72		RGS19_HUMAN (24-189): 2.24e-60: 189: 35.54
+	Hs
		989889 GNAI1_HUMAN (1-354): 0: 516: 99.72		RGS17_HUMAN (33-188): 5.34e-60: 188: 33.97
+	Hs
		476047 GNAI3_HUMAN (1-354): 0: 508: 94.07		RGS18_HUMAN (15-179): 1.32e-60: 191: 47.88
+	Hs
		168040 GNAI1_HUMAN (1-354): 0: 516: 99.72		RGS12_HUMAN (44-176): 4.25e-52: 181: 39.26
+	Hs
		220444 GNAI1_HUMAN (1-354): 0: 516: 99.72		RGS14_HUMAN (36-203): 1.09e-53: 181: 34.10
+	Hs
		475922 GNAI3_HUMAN (1-354): 0: 508: 94.07		RGS19_HUMAN (24-189): 2.24e-60: 189: 35.54
+	Hs
		475908 GNAI3_HUMAN (1-354): 0: 508: 94.07		RGS2_HUMAN (10-189): 3.1e-58: 184: 43.96
+	Hs
		168030 GNAI3_HUMAN (1-354): 0: 508: 94.07		RGS12_HUMAN (44-176): 4.25e-52: 181: 39.26
+	Hs
		220434 GNAI3_HUMAN (1-354): 0: 508: 94.07		RGS14_HUMAN (36-203): 1.09e-53: 181: 34.10
+	Hs
		223468 GNAI1_HUMAN (1-354): 0: 516: 99.72		RGS10_HUMAN (58-175): 2.84e-25: 98.6: 44.92
+	Hs
		223463 GNAI3_HUMAN (1-354): 0: 508: 94.07		RGS10_HUMAN (58-175): 2.84e-25: 98.6: 44.92