Protein: RGS2
Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8)

Gene: RGS2
Organism: Homo sapiens
Interactions: 78
UniProt ID: P41220

Gene Ontology (top 5):
GO:0001965 - G-protein alpha-subunit binding
GO:0001975 - response to amphetamine
GO:0003924 - GTPase activity
GO:0005096 - GTPase activator activity
GO:0005516 - calmodulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

833437

STK26
Serine/threonine-protein kinase 26

2

2

High-throughput

0.811

High

833421

WDR74
WD repeat-containing protein 74

2

4

High-throughput

0.801

High

302769

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

2

2

High-throughput

0.783

High

833411

KGP1
cGMP-dependent protein kinase 1

1

4

Small-scale

0.724

High

833418

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

Small-scale

0.691

High

833446

NINL
Ninein-like protein

3

3

High-throughput

0.678

High

240973

PRKN
E3 ubiquitin-protein ligase parkin

3

3

High-throughput

0.672

High

833417

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

4

High-throughput

0.654

High

424643

KPCG
Protein kinase C gamma type

1

4

Small-scale

0.647

High

436626

KPCB
Protein kinase C beta type

1

3

Small-scale

0.647

High

475908

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

20

Small-scale

0.647

High

603193

KPCA
Protein kinase C alpha type

1

3

Small-scale

0.647

High

721445

GNA15
Guanine nucleotide-binding protein subunit alpha-15

1

20

Small-scale

0.647

High

833397

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

20

Small-scale

0.647

High

833403

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

20

Small-scale

0.647

High

833429

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

2

High-throughput

0.628

High

536661

HSP7C
Heat shock cognate 71 kDa protein

2

1

High-throughput

0.620

High

833406

DDR1
Epithelial discoidin domain-containing receptor 1

2

3

High-throughput

0.620

High

833447

GIT1
ARF GTPase-activating protein GIT1

2

4

High-throughput

0.620

High

833398

MAP2
Methionine aminopeptidase 2

2

0

High-throughput

0.602

High

833408

PTN13
Tyrosine-protein phosphatase non-receptor type 13

2

0

High-throughput

0.602

High

833419

STRP1
Striatin-interacting protein 1

2

0

High-throughput

0.602

High

833428

MIPO1
Mirror-image polydactyly gene 1 protein

2

0

High-throughput

0.602

High

833404

DYL1
Dynein light chain 1, cytoplasmic

2

0

High-throughput

0.594

High

833430

NIPS1
Protein NipSnap homolog 1

2

0

High-throughput

0.594

High

833436

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

2

0

High-throughput

0.594

High

833440

VPS29
Vacuolar protein sorting-associated protein 29

2

0

High-throughput

0.594

High

833422

STXB4
Syntaxin-binding protein 4

2

8

High-throughput

0.574

High

833416

DDB1
DNA damage-binding protein 1

2

0

Small-scale

0.559

High

833432

FBX44
F-box only protein 44

2

0

Small-scale

0.559

High

240183

KLK8
Kallikrein-8

1

1

High-throughput

0.541

High

833402

RAP1B
Ras-related protein Rap-1b

1

9

High-throughput

0.541

High

340443

ADCY5
Adenylate cyclase type 5

1

0

Small-scale

0.537

High

833443

NEB1
Neurabin-1

1

5

Small-scale

0.527

High

833435

GDE1
Glycerophosphodiester phosphodiesterase 1

1

1

Small-scale

0.527

High

483037

CLCA
Clathrin light chain A

1

0

High-throughput

0.518

High

833409

FZD5
Frizzled-5

1

0

High-throughput

0.518

High

833424

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.518

High

833399

H2BFS
Histone H2B type F-S

1

4

High-throughput

0.515

High

833438

IBTK
Inhibitor of Bruton tyrosine kinase

1

2

High-throughput

0.515

High

380828

MYG
Myoglobin

1

0

High-throughput

0.513

High

833420

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.513

High

833434

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.513

High

833445

NISCH
Nischarin

1

0

High-throughput

0.513

High

507642

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.508

High

517623

ZBT48
Zinc finger and BTB domain-containing protein 48

1

1

High-throughput

0.508

High

833412

DPYL1
Dihydropyrimidinase-related protein 1

1

1

High-throughput

0.508

High

833415

ZYX
Zyxin

1

3

High-throughput

0.508

High

833425

ZN579
Zinc finger protein 579

1

2

High-throughput

0.508

High

833427

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.508

High

362908

EGFR
Epidermal growth factor receptor

1

4

Small-scale

0.501

High

833400

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.493

High

322375

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.486

High

339323

MET18
Histidine protein methyltransferase 1 homolog

1

0

High-throughput

0.486

High

349389

TSN15
Tetraspanin-15

1

0

High-throughput

0.486

High

557918

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.486

High

617430

DNLI1
DNA ligase 1

1

0

High-throughput

0.486

High

642206

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.486

High

833401

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.486

High

833407

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.486

High

833423

MON1A
Vacuolar fusion protein MON1 homolog A

1

0

High-throughput

0.486

High

833431

TBB2B
Tubulin beta-2B chain

1

0

High-throughput

0.486

High

833433

DUS21
Dual specificity protein phosphatase 21

1

0

High-throughput

0.486

High

833439

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.486

High

833441

PRAF1
Prenylated Rab acceptor protein 1

1

0

High-throughput

0.486

High

833444

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.486

High

458313

ADRB2
Beta-2 adrenergic receptor

1

8

Small-scale

0.481

High

833410

CUL4B
Cullin-4B

1

4

Small-scale

0.479

High

833414

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.458

High

833413

SCN5A
Sodium channel protein type 5 subunit alpha

1

0

High-throughput

0.438

High

833442

ZPI
Protein Z-dependent protease inhibitor

2

0

High-throughput

0.328

High

571390

GLU2B
Glucosidase 2 subunit beta

2

0

High-throughput

0.323

High

246277

MARH6
E3 ubiquitin-protein ligase MARCHF6

2

0

Small-scale

0.316

High

460782

CATB
Cathepsin B

2

0

High-throughput

0.307

High

450222

HYEP
Epoxide hydrolase 1

1

0

High-throughput

0.279

Low

833405

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.265

Low

833426

BBS10
BBSome complex assembly protein BBS10

1

0

High-throughput

0.265

Low

833448

IR3IP
Immediate early response 3-interacting protein 1

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025