HitPredict

Interactor 1: CXCL2 (P10889)
C-X-C motif chemokine 2 (Macrophage inflammatory protein 2) (MIP2)
Gene: CXCL2

Interactor 2: MMP12 (P34960)
Macrophage metalloelastase (MME) (EC 3.4.24.65) (Matrix metalloproteinase-12) (MMP-12)
Gene: MMP12

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	18660381
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 100 Mm			1 473
+	Mm
		762099 CXCL3_MOUSE (1-100): 2.13e-32: 110: 82.00		MMP12_MOUSE (1-473): 0: 647: 100.00
+	Hs
		626423 CXCL2_HUMAN (22-100): 2.39e-28: 100: 63.29		MMP12_HUMAN (12-473): 0: 647: 61.57
+	Mm
		762098 CXCL5_MOUSE (4-98): 2.88e-27: 98.2: 47.48		MMP12_MOUSE (1-473): 0: 647: 100.00
+	Hs
		390322 CXCL7_HUMAN (30-99): 8.57e-27: 97: 54.29		MMP12_HUMAN (12-473): 0: 647: 61.57
+	Hs
		814894 CXCL5_HUMAN (20-97): 4.98e-27: 97: 47.44		MMP12_HUMAN (12-473): 0: 647: 61.57
+	Mm
		556548 GROA_MOUSE (26-96): 5.86e-27: 96.6: 69.01		MMP12_MOUSE (1-473): 0: 647: 100.00
+	Hs
		480488 GROA_HUMAN (30-100): 1.73e-26: 95.5: 66.20		MMP12_HUMAN (12-473): 0: 647: 61.57
+	Hs
		626440 CXCL3_HUMAN (30-100): 3.53e-26: 94.7: 69.01		MMP12_HUMAN (12-473): 0: 647: 61.57
+	Hs
		814897 CXCL6_HUMAN (23-97): 9.51e-25: 91.2: 50.67		MMP12_HUMAN (12-473): 0: 647: 61.57
+	Hs
		399268 CXCL2_HUMAN (22-100): 2.39e-28: 100: 63.29		MMP1_HUMAN (32-473): 0: 609: 45.60
+	Hs
		390313 CXCL7_HUMAN (30-99): 8.57e-27: 97: 54.29		MMP1_HUMAN (32-473): 0: 609: 45.60
+	Hs
		399270 CXCL5_HUMAN (20-97): 4.98e-27: 97: 47.44		MMP1_HUMAN (32-473): 0: 609: 45.60
+	Hs
		399275 CXCL6_HUMAN (23-97): 9.51e-25: 91.2: 50.67		MMP1_HUMAN (32-473): 0: 609: 45.60
+	Hs
		653760 CXCL5_HUMAN (20-97): 4.98e-27: 97: 47.44		MMP8_HUMAN (23-473): 0: 603: 43.74
+	Hs
		399261 IL8_HUMAN (31-100): 4.65e-23: 86.6: 43.66		MMP1_HUMAN (32-473): 0: 609: 45.60
+	Hs
		575777 CXCL2_HUMAN (22-100): 2.39e-28: 100: 63.29		MMP9_HUMAN (31-210): 1.35e-67: 231: 43.33
+	Hs
		390316 CXCL7_HUMAN (30-99): 8.57e-27: 97: 54.29		MMP9_HUMAN (31-210): 1.35e-67: 231: 43.33
+	Hs
		575782 CXCL5_HUMAN (20-97): 4.98e-27: 97: 47.44		MMP9_HUMAN (31-210): 1.35e-67: 231: 43.33
+	Hs
		575783 CXCL6_HUMAN (23-97): 9.51e-25: 91.2: 50.67		MMP9_HUMAN (31-210): 1.35e-67: 231: 43.33
+	Hs
		518756 IL8_HUMAN (31-100): 4.65e-23: 86.6: 43.66		MMP9_HUMAN (31-210): 1.35e-67: 231: 43.33