HitPredict

Interactor 1: GROA (P12850)
Growth-regulated alpha protein (C-X-C motif chemokine 1) (Platelet-derived growth factor-inducible protein KC) (Secretory protein N51) [Cleaved into: KC(5-72) (Hematopoietic synergistic factor) (HSF) (KC-T)]
Gene: Cxcl1

Interactor 2: MMP12 (P34960)
Macrophage metalloelastase (MME) (EC 3.4.24.65) (Matrix metalloproteinase-12) (MMP-12)
Gene: MMP12

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	18660381
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 96 Mm			1 473
+	Hs
		626423 CXCL2_HUMAN (2-92): 5.31e-29: 101: 64.84		MMP12_HUMAN (12-473): 0: 647: 61.57
+	Mm
		533539 CXCL2_MOUSE (18-91): 8.77e-29: 100: 68.92		MMP12_MOUSE (1-473): 0: 647: 100.00
+	Mm
		762099 CXCL3_MOUSE (18-92): 1.16e-27: 98.2: 60.00		MMP12_MOUSE (1-473): 0: 647: 100.00
+	Hs
		814894 CXCL5_HUMAN (22-93): 3.58e-27: 97.4: 52.78		MMP12_HUMAN (12-473): 0: 647: 61.57
+	Hs
		390322 CXCL7_HUMAN (30-93): 2.33e-26: 95.9: 65.63		MMP12_HUMAN (12-473): 0: 647: 61.57
+	Mm
		762098 CXCL5_MOUSE (9-91): 2.18e-26: 95.9: 49.43		MMP12_MOUSE (1-473): 0: 647: 100.00
+	Hs
		480488 GROA_HUMAN (27-91): 7.39e-26: 94: 70.77		MMP12_HUMAN (12-473): 0: 647: 61.57
+	Hs
		626440 CXCL3_HUMAN (27-91): 3.27e-25: 92: 69.23		MMP12_HUMAN (12-473): 0: 647: 61.57
+	Hs
		814897 CXCL6_HUMAN (22-92): 1.02e-24: 91.3: 45.07		MMP12_HUMAN (12-473): 0: 647: 61.57
+	Hs
		399268 CXCL2_HUMAN (2-92): 5.31e-29: 101: 64.84		MMP1_HUMAN (32-473): 0: 609: 45.60
+	Hs
		399270 CXCL5_HUMAN (22-93): 3.58e-27: 97.4: 52.78		MMP1_HUMAN (32-473): 0: 609: 45.60
+	Hs
		390313 CXCL7_HUMAN (30-93): 2.33e-26: 95.9: 65.63		MMP1_HUMAN (32-473): 0: 609: 45.60
+	Hs
		653760 CXCL5_HUMAN (22-93): 3.58e-27: 97.4: 52.78		MMP8_HUMAN (23-473): 0: 603: 43.74
+	Hs
		399275 CXCL6_HUMAN (22-92): 1.02e-24: 91.3: 45.07		MMP1_HUMAN (32-473): 0: 609: 45.60
+	Hs
		399261 IL8_HUMAN (28-92): 7.52e-23: 85.9: 53.03		MMP1_HUMAN (32-473): 0: 609: 45.60
+	Hs
		575777 CXCL2_HUMAN (2-92): 5.31e-29: 101: 64.84		MMP9_HUMAN (31-210): 1.35e-67: 231: 43.33
+	Hs
		575782 CXCL5_HUMAN (22-93): 3.58e-27: 97.4: 52.78		MMP9_HUMAN (31-210): 1.35e-67: 231: 43.33
+	Hs
		390316 CXCL7_HUMAN (30-93): 2.33e-26: 95.9: 65.63		MMP9_HUMAN (31-210): 1.35e-67: 231: 43.33
+	Hs
		575783 CXCL6_HUMAN (22-92): 1.02e-24: 91.3: 45.07		MMP9_HUMAN (31-210): 1.35e-67: 231: 43.33
+	Hs
		518756 IL8_HUMAN (28-92): 7.52e-23: 85.9: 53.03		MMP9_HUMAN (31-210): 1.35e-67: 231: 43.33