HitPredict

Interactor 1: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Interactor 2: NEK7 (Q8TDX7)
Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7)
Gene: NEK7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 803 Hs			1 302
+	Hs
		538446 ENPL_HUMAN (1-803): 0: 1073: 100.00		AKT3_HUMAN (2-294): 6.75e-126: 369: 23.43
+	Hs
		538122 ENPL_HUMAN (1-803): 0: 1073: 100.00		AKT1_HUMAN (6-294): 3.82e-124: 365: 23.05
+	Hs
		437928 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT2_HUMAN (7-294): 2.03e-127: 373: 24.92
+	Hs
		438633 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT3_HUMAN (2-294): 6.75e-126: 369: 23.43
+	Bt
		964601 HS90B_BOVIN (75-783): 0: 997: 46.68		AKT1_BOVIN (6-294): 1.58e-125: 368: 23.73
+	Mm
		513660 HS90B_MOUSE (75-783): 0: 998: 46.26		AKT1_MOUSE (6-296): 1.58e-124: 366: 22.90
+	Hs
		431573 HS90A_HUMAN (60-783): 0: 990: 45.34		AKT2_HUMAN (7-294): 2.03e-127: 373: 24.92
+	Hs
		437927 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT1_HUMAN (6-294): 3.82e-124: 365: 23.05
+	Hs
		431572 HS90A_HUMAN (60-783): 0: 990: 45.34		AKT1_HUMAN (6-294): 3.82e-124: 365: 23.05
+	Hs
		160340 HS90B_HUMAN (75-783): 0: 997: 46.54		AURKA_HUMAN (2-301): 1.63e-118: 348: 26.30
+	Hs
		160336 HS90A_HUMAN (60-783): 0: 990: 45.34		AURKA_HUMAN (2-301): 1.63e-118: 348: 26.30
+	Hs
		438513 HS90B_HUMAN (75-783): 0: 997: 46.54		NUAK2_HUMAN (5-291): 1.47e-104: 319: 27.08
+	Hs
		431792 HS90A_HUMAN (60-783): 0: 990: 45.34		STK4_HUMAN (4-292): 8.3e-105: 315: 27.93
+	Hs
		538285 ENPL_HUMAN (1-803): 0: 1073: 100.00		NEK10_HUMAN (31-288): 1.88e-46: 169: 33.71
+	Hs
		438015 HS90B_HUMAN (75-783): 0: 997: 46.54		NEK4_HUMAN (31-285): 1.86e-53: 188: 40.23
+	Hs
		431675 HS90A_HUMAN (60-783): 0: 990: 45.34		NEK4_HUMAN (31-285): 1.86e-53: 188: 40.23
+	Hs
		438311 HS90B_HUMAN (75-783): 0: 997: 46.54		NEK8_HUMAN (40-288): 1.58e-51: 181: 40.40
+	Hs
		438382 HS90B_HUMAN (75-783): 0: 997: 46.54		NEK9_HUMAN (40-290): 1.05e-48: 175: 39.29
+	Hs
		438369 HS90B_HUMAN (75-783): 0: 997: 46.54		NEK11_HUMAN (34-291): 5.4e-47: 168: 34.35
+	Hs
		438014 HS90B_HUMAN (75-783): 0: 997: 46.54		NEK2_HUMAN (33-290): 1.01e-47: 167: 35.85