Protein: PYC1
Pyruvate carboxylase 1 (EC 6.4.1.1) (Pyruvic carboxylase 1) (PCB 1)

Gene: PYC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 48
UniProt ID: P11154

Gene Ontology (top 5):
GO:0004736 - pyruvate carboxylase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006090 - pyruvate metabolic process
GO:0006094 - gluconeogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

538329

PYC2
Pyruvate carboxylase 2

3

17

High-throughput

0.836

High

538314

PYC1
Pyruvate carboxylase 1

1

17

High-throughput

0.590

High

538316

KSS1
Mitogen-activated protein kinase KSS1

1

5

High-throughput

0.536

High

538326

SBA1
Co-chaperone protein SBA1

1

2

Small-scale

0.527

High

470089

SPS1
Sporulation-specific protein 1

1

12

High-throughput

0.515

High

538318

PHO85
Cyclin-dependent protein kinase PHO85

1

7

High-throughput

0.501

High

538322

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

1

High-throughput

0.501

High

538339

RSP5
E3 ubiquitin-protein ligase RSP5

1

11

High-throughput

0.501

High

538321

PP11
Serine/threonine-protein phosphatase PP1-1

1

4

High-throughput

0.500

High

538330

ARP2
Actin-related protein 2

1

2

High-throughput

0.500

High

538335

VPS21
Vacuolar protein sorting-associated protein 21

1

3

High-throughput

0.500

High

538342

RIM15
Serine/threonine-protein kinase RIM15

1

8

High-throughput

0.500

High

538354

ATG5
Autophagy protein 5

1

2

High-throughput

0.500

High

458989

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.489

High

538344

ENT3
Epsin-3

1

0

Small-scale

0.480

High

454685

KAPR
cAMP-dependent protein kinase regulatory subunit

1

4

Small-scale

0.479

High

538319

PHO81
Phosphate system positive regulatory protein PHO81

1

3

High-throughput

0.479

High

538323

SIS1
Protein SIS1

1

4

High-throughput

0.479

High

538325

CDC48
Cell division control protein 48

1

5

High-throughput

0.479

High

538332

ZUO1
Zuotin

1

3

Small-scale

0.479

High

538333

RAD5
DNA repair protein RAD5

1

5

High-throughput

0.479

High

538337

KPR2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.479

High

538356

SMC6
Structural maintenance of chromosomes protein 6

1

6

High-throughput

0.479

High

538317

AMPL
Vacuolar aminopeptidase 1

1

1

High-throughput

0.457

High

538320

FKBP
FK506-binding protein 1

1

1

High-throughput

0.457

High

525746

HSP72
Heat shock protein SSA2

1

12

High-throughput

0.445

High

538340

SSB2
Ribosome-associated molecular chaperone SSB2

1

13

High-throughput

0.445

High

538315

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.437

High

538327

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

538328

BMH1
Protein BMH1

1

4

High-throughput

0.437

High

538338

UME6
Transcriptional regulatory protein UME6

1

4

High-throughput

0.437

High

538345

INP52
Polyphosphatidylinositol phosphatase INP52

1

1

High-throughput

0.437

High

538346

CDH1
APC/C activator protein CDH1

1

15

Small-scale

0.437

High

538347

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.437

High

538351

YL352
F-box protein YLR352W

1

1

High-throughput

0.437

High

538352

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

538353

AP3D
AP-3 complex subunit delta

1

3

High-throughput

0.437

High

538324

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.279

Low

538331

CDC12
Cell division control protein 12

1

0

High-throughput

0.279

Low

538349

SML1
Ribonucleotide reductase inhibitor protein SML1

1

0

High-throughput

0.279

Low

538334

PRP40
Pre-mRNA-processing protein PRP40

1

0

High-throughput

0.261

Low

538341

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

High-throughput

0.261

Low

538343

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.261

Low

538336

TSL1
Trehalose synthase complex regulatory subunit TSL1

1

0

High-throughput

0.249

Low

538348

ULP1
Ubiquitin-like-specific protease 1

1

0

High-throughput

0.249

Low

538350

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

538355

ATG11
Autophagy-related protein 11

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025