HitPredict

Interactor 1: SYDC (P14868)
Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein)
Gene: DARS1

Interactor 2: SYIC (P41252)
Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)
Gene: IARS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 36347866
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0017101 - aminoacyl-tRNA synthetase multienzyme complex and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 1262
+	Hs
		783040 SYK_HUMAN (14-495): 2.23e-154: 454: 18.88		SYIC_HUMAN (1-1262): 0: 1480: 100.00
+	Dm
		1178626 Q7K0E6_DROME (19-501): 0: 562: 68.66		Q8MSW0_DROME (4-1202): 0: 1190: 53.75
+	Sc
		450305 SYNC_YEAST (5-501): 6.15e-165: 479: 25.44		SYIC_YEAST (2-1071): 0: 1020: 52.93
+	Sc
		389036 SYDC_YEAST (9-501): 0: 530: 56.46		SYV_YEAST (7-962): 0: 755: 18.88
+	Hs
		541427 SYDC_HUMAN (1-501): 0: 617: 100.00		SYLC_HUMAN (3-993): 0: 668: 16.08
+	Sc
		430774 SYNC_YEAST (5-501): 6.15e-165: 479: 25.44		SYV_YEAST (7-962): 0: 755: 18.88
+	Ec
		343736 SYK2_ECOLI (9-496): 2.17e-153: 448: 20.70		SYI_ECOLI (3-914): 0: 731: 23.66
+	Sc
		430745 SYKC_YEAST (12-493): 1.1e-140: 418: 18.88		SYV_YEAST (7-962): 0: 755: 18.88
+	Hs
		1065588 SYK_HUMAN (14-495): 2.23e-154: 454: 18.88		SYLC_HUMAN (3-993): 0: 668: 16.08