HitPredict

Interactor 1: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Interactor 2: TAL2 (Q16559)
T-cell acute lymphocytic leukemia protein 2 (TAL-2) (Class A basic helix-loop-helix protein 19) (bHLHa19)
Gene: TAL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0003677 - DNA binding GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 654 Hs			1 108
+	Hs
		551521 TFE2_HUMAN (1-654): 0: 907: 100.00		NDF1_HUMAN (3-101): 2.18e-27: 104: 33.98
+	Hs
		551544 TFE2_HUMAN (1-654): 0: 907: 100.00		PTF1A_HUMAN (4-108): 9.86e-28: 104: 35.14
+	Hs
		526739 TFE2_HUMAN (1-654): 0: 907: 100.00		MYF5_HUMAN (1-100): 5.72e-28: 103: 30.00
+	Hs
		551577 TFE2_HUMAN (1-654): 0: 907: 100.00		NDF4_HUMAN (2-86): 5.04e-27: 102: 34.12
+	Hs
		551564 TFE2_HUMAN (1-654): 0: 907: 100.00		ATOH1_HUMAN (2-108): 1.3e-26: 101: 30.91
+	Hs
		551565 TFE2_HUMAN (1-654): 0: 907: 100.00		NGN1_HUMAN (2-108): 2.22e-27: 101: 31.53
+	Hs
		551594 TFE2_HUMAN (1-654): 0: 907: 100.00		NGN3_HUMAN (2-104): 6.67e-27: 100: 33.01
+	Hs
		551472 TFE2_HUMAN (1-654): 0: 907: 100.00		MYF6_HUMAN (2-107): 2.01e-26: 99.7: 23.59
+	Hs
		551490 TFE2_HUMAN (1-654): 0: 907: 100.00		HAND2_HUMAN (1-78): 3.15e-26: 98.5: 41.03
+	Hs
		551515 TFE2_HUMAN (1-654): 0: 907: 100.00		TCF15_HUMAN (3-103): 9.84e-26: 96.6: 37.74
+	Hs
		551530 TFE2_HUMAN (1-654): 0: 907: 100.00		TWST1_HUMAN (2-66): 6.25e-25: 94.7: 53.85
+	Hs
		524532 TFE2_HUMAN (1-654): 0: 907: 100.00		LYL1_HUMAN (1-108): 4.26e-24: 94.3: 47.22
+	Hs
		551464 TFE2_HUMAN (1-654): 0: 907: 100.00		TAL1_HUMAN (1-104): 8.18e-24: 94.3: 53.21
+	Hs
		551559 TFE2_HUMAN (1-654): 0: 907: 100.00		TWST2_HUMAN (2-66): 5.44e-25: 93.5: 52.31
+	Hs
		551569 TFE2_HUMAN (1-654): 0: 907: 100.00		FER3L_HUMAN (2-67): 1.03e-23: 90.4: 40.91
+	Hs
		551547 TFE2_HUMAN (1-654): 0: 907: 100.00		SCX_HUMAN (3-58): 1.76e-22: 88.5: 57.14
+	Hs
		551505 TFE2_HUMAN (1-654): 0: 907: 100.00		HEN2_HUMAN (9-58): 3.2e-22: 85.8: 66.00
+	Hs
		551504 TFE2_HUMAN (1-654): 0: 907: 100.00		HEN1_HUMAN (4-58): 6.58e-22: 85: 60.00
+	Hs
		330420 TFE2_HUMAN (1-654): 0: 907: 100.00		HAND1_HUMAN (3-65): 6.69e-21: 84.7: 47.62
+	Rn
		600265 TFE2_RAT (1-654): 0: 879: 81.83		Q9EPJ1_RAT (2-66): 2.37e-25: 95.8: 53.85