HitPredict

Interactor 1: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Interactor 2: ASCL4 (Q6XD76)
Achaete-scute homolog 4 (ASH-4) (hASH4) (Achaete-scute-like protein 4) (Class A basic helix-loop-helix protein 44) (bHLHa44)
Gene: ASCL4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0006357 - regulation of transcription by RNA polymerase II GO:0090575 - RNA polymerase II transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 654 Hs			1 172
+	Hs
		551486 TFE2_HUMAN (1-654): 0: 907: 100.00		ASCL1_HUMAN (16-170): 7.3e-31: 113: 34.59
+	Hs
		551544 TFE2_HUMAN (1-654): 0: 907: 100.00		PTF1A_HUMAN (19-171): 9.47e-30: 112: 26.35
+	Hs
		551490 TFE2_HUMAN (1-654): 0: 907: 100.00		HAND2_HUMAN (6-171): 3.49e-30: 111: 21.18
+	Hs
		551559 TFE2_HUMAN (1-654): 0: 907: 100.00		TWST2_HUMAN (22-167): 3.67e-30: 109: 21.23
+	Hs
		545932 TFE2_HUMAN (1-654): 0: 907: 100.00		MYOD1_HUMAN (5-166): 5.86e-28: 107: 27.98
+	Hs
		551540 TFE2_HUMAN (1-654): 0: 907: 100.00		FIGLA_HUMAN (13-161): 3.88e-28: 106: 26.32
+	Hs
		526739 TFE2_HUMAN (1-654): 0: 907: 100.00		MYF5_HUMAN (21-168): 9.52e-28: 105: 23.90
+	Hs
		524532 TFE2_HUMAN (1-654): 0: 907: 100.00		LYL1_HUMAN (55-168): 6.19e-27: 104: 30.23
+	Hs
		551472 TFE2_HUMAN (1-654): 0: 907: 100.00		MYF6_HUMAN (13-170): 8.43e-27: 103: 22.42
+	Hs
		551543 TFE2_HUMAN (1-654): 0: 907: 100.00		BHA15_HUMAN (2-160): 2.86e-27: 103: 24.38
+	Hs
		546066 TFE2_HUMAN (1-654): 0: 907: 100.00		MYOG_HUMAN (12-167): 1.65e-26: 101: 23.72
+	Hs
		551515 TFE2_HUMAN (1-654): 0: 907: 100.00		TCF15_HUMAN (41-171): 2.06e-26: 101: 21.48
+	Hs
		210857 TFE2_HUMAN (1-654): 0: 907: 100.00		TCF21_HUMAN (29-139): 1.93e-26: 100: 22.52
+	Hs
		330420 TFE2_HUMAN (1-654): 0: 907: 100.00		HAND1_HUMAN (3-170): 3.87e-26: 100: 20.81
+	Hs
		551533 TFE2_HUMAN (1-654): 0: 907: 100.00		TAL2_HUMAN (73-169): 4.26e-27: 99: 32.04
+	Hs
		551505 TFE2_HUMAN (1-654): 0: 907: 100.00		HEN2_HUMAN (1-129): 3.36e-26: 98.4: 25.37
+	Hs
		551565 TFE2_HUMAN (1-654): 0: 907: 100.00		NGN1_HUMAN (72-172): 6.65e-23: 92.6: 34.62
+	Hs
		551564 TFE2_HUMAN (1-654): 0: 907: 100.00		ATOH1_HUMAN (53-152): 6.64e-22: 92.2: 33.98
+	Hs
		551464 TFE2_HUMAN (1-654): 0: 907: 100.00		TAL1_HUMAN (57-161): 7.57e-22: 91.5: 30.28
+	Hs
		551547 TFE2_HUMAN (1-654): 0: 907: 100.00		SCX_HUMAN (77-128): 2.06e-10: 58.7: 50.00