HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: OCRL (Q01968)
Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86)
Gene: OCRL

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 901
+	Hs
		226647 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		I5P2_HUMAN (143-897): 0: 719: 50.27
+	Mm
		88466 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		D3Z656_MOUSE (218-732): 1.39e-120: 402: 24.58
+	Hs
		228249 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SHIP1_HUMAN (204-743): 3.04e-103: 349: 21.23
+	Hs
		228525 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		INP5K_HUMAN (227-571): 1.28e-106: 338: 28.85
+	Hs
		475170 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		INP5K_HUMAN (227-571): 1.28e-106: 338: 28.85
+	Hs
		176358 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SHIP2_HUMAN (184-644): 2.78e-101: 344: 24.95
+	Dm
		1179001 Q9W418_DROME (1-77): 5.42e-30: 124: 32.47		Q7K161_DROME (235-581): 4.9e-103: 325: 31.78
+	At
		1092068 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		IP5P2_ARATH (171-310): 7.14e-18: 90.5: 25.00