HitPredict

Interactor 1: PSA1 (P12881)
Proteasome subunit alpha type-1 (PROS-Dm35) (Proteasome 35 kDa subunit)
Gene: Prosalpha6

Interactor 2: Q7K148 (Q7K148)
Proteasome subunit beta
Gene: Prosbeta5

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.934

Property	Details
Experiments	23738891, 23457214, 25294943, 22036573, 19079254, 38944040
Identification Methods	affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 279 Dm			1 282
+	Hs
		680776 PSA1_HUMAN (1-269): 1.17e-102: 301: 52.42		PSB8_HUMAN (1-277): 5.11e-103: 303: 48.74
+	Dm
		556702 PSA1_DROME (1-279): 8.23e-111: 322: 100.00		Q8T8V8_DROME (1-282): 1.52e-91: 275: 59.01
+	Dm
		556706 PSA1_DROME (1-279): 8.23e-111: 322: 100.00		PSA5_DROME (40-273): 3.61e-89: 266: 17.48
+	Hs
		680778 PSA1_HUMAN (1-269): 1.17e-102: 301: 52.42		PSA5_HUMAN (40-272): 3.49e-90: 269: 18.52
+	Ss
		99238 F2Z5L7_PIG (1-269): 1.17e-102: 301: 52.42		F2Z5K2_PIG (40-272): 3.49e-90: 269: 18.52
+	Hs
		680781 PSA1_HUMAN (1-269): 1.17e-102: 301: 52.42		PSB5_HUMAN (1-277): 1.25e-88: 266: 51.63
+	At
		307135 PSA6B_ARATH (6-243): 1.14e-105: 308: 32.92		PSB7B_ARATH (41-262): 2.25e-85: 258: 27.75
+	At
		200651 PSA6B_ARATH (6-243): 1.14e-105: 308: 32.92		PSB7A_ARATH (41-262): 6.47e-85: 257: 27.75
+	Dm
		556825 PSA1_DROME (1-279): 8.23e-111: 322: 100.00		Q9W470_DROME (47-267): 1.25e-77: 239: 28.51
+	Ss
		99114 F2Z5L7_PIG (1-269): 1.17e-102: 301: 52.42		F1SBA5_PIG (43-266): 3.64e-86: 259: 17.67
+	Hs
		680771 PSA1_HUMAN (1-269): 1.17e-102: 301: 52.42		PSA4_HUMAN (43-269): 1.68e-85: 258: 17.30
+	Hs
		165260 PSA1_HUMAN (1-269): 1.17e-102: 301: 52.42		PSA7_HUMAN (46-270): 9.36e-85: 255: 15.88
+	Dm
		556703 PSA1_DROME (1-279): 8.23e-111: 322: 100.00		Q8T915_DROME (30-255): 1.31e-74: 232: 26.96
+	Hs
		680800 PSA1_HUMAN (1-269): 1.17e-102: 301: 52.42		PSB10_HUMAN (47-256): 1.79e-83: 253: 29.05
+	Dm
		556798 PSA1_DROME (1-279): 8.23e-111: 322: 100.00		Q9VUJ1_DROME (47-267): 5.17e-75: 231: 27.60
+	Hs
		680962 PSA1_HUMAN (1-269): 1.17e-102: 301: 52.42		PSMA8_HUMAN (43-269): 4.69e-76: 233: 17.08
+	Hs
		680997 PSA1_HUMAN (1-269): 1.17e-102: 301: 52.42		PSB7_HUMAN (39-265): 2.89e-75: 232: 28.63
+	Hs
		680780 PSA1_HUMAN (1-269): 1.17e-102: 301: 52.42		PSB6_HUMAN (69-259): 1.62e-73: 226: 30.21
+	Dm
		47741 PSA1_DROME (1-279): 8.23e-111: 322: 100.00		A0AQH0_DROME (73-256): 1.52e-18: 84: 29.57
+	Hs
		680777 PSA1_HUMAN (1-269): 1.17e-102: 301: 52.42		PSB9_HUMAN (73-256): 2.24e-19: 85.9: 30.98