HitPredict

Interactor 1: PGFRA (P16234)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene: PDGFRA

Interactor 2: RASA1 (P20936)
Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)
Gene: RASA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	7682895
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1089 Hs			1 1047
+	Hs
		452350 PGFRB_HUMAN (29-1089): 0: 650: 43.33		RASA1_HUMAN (1-1047): 0: 824: 100.00
+	Hs
		499231 KIT_HUMAN (18-978): 0: 559: 33.64		RASA1_HUMAN (1-1047): 0: 824: 100.00
+	Hs
		596366 FLT3_HUMAN (4-979): 1e-158: 498: 27.84		RASA1_HUMAN (1-1047): 0: 824: 100.00
+	Hs
		596365 VGFR2_HUMAN (7-588): 8.16e-51: 198: 17.81		RASA1_HUMAN (1-1047): 0: 824: 100.00
+	Hs
		452472 PGFRB_HUMAN (29-1089): 0: 650: 43.33		SYGP1_HUMAN (375-1030): 6.69e-106: 362: 19.45
+	Hs
		557099 PGFRA_HUMAN (1-1089): 0: 817: 100.00		PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94
+	Hs
		557088 PGFRA_HUMAN (1-1089): 0: 817: 100.00		GRB2_HUMAN (181-317): 1.08e-10: 64.3: 30.71
+	Hs
		452399 PGFRB_HUMAN (29-1089): 0: 650: 43.33		PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94
+	Hs
		452385 PGFRB_HUMAN (29-1089): 0: 650: 43.33		GRB2_HUMAN (181-317): 1.08e-10: 64.3: 30.71
+	Hs
		499259 KIT_HUMAN (18-978): 0: 559: 33.64		PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94
+	Hs
		499253 KIT_HUMAN (18-978): 0: 559: 33.64		GRB2_HUMAN (181-317): 1.08e-10: 64.3: 30.71
+	Hs
		499264 KIT_HUMAN (18-978): 0: 559: 33.64		GRAP_HUMAN (181-317): 3.7e-10: 62.8: 28.26
+	Hs
		738197 FLT3_HUMAN (4-979): 1e-158: 498: 27.84		PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94
+	Hs
		738192 FLT3_HUMAN (4-979): 1e-158: 498: 27.84		GRB2_HUMAN (181-317): 1.08e-10: 64.3: 30.71
+	Hs
		609394 FGFR3_HUMAN (745-969): 1.84e-76: 270: 40.74		IQGA3_HUMAN (401-1044): 1.11e-77: 281: 12.22
+	Hs
		924527 MERTK_HUMAN (121-1073): 2.64e-131: 425: 17.11		GRB2_HUMAN (181-317): 1.08e-10: 64.3: 30.71
+	Hs
		609260 FGFR3_HUMAN (745-969): 1.84e-76: 270: 40.74		PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94
+	Hs
		609244 FGFR3_HUMAN (745-969): 1.84e-76: 270: 40.74		GRB2_HUMAN (181-317): 1.08e-10: 64.3: 30.71
+	Rn
		783507 NTRK2_RAT (87-776): 3.54e-53: 202: 14.10		PTN11_RAT (168-347): 1.18e-25: 115: 24.63
+	Mm
		546284 NTRK2_MOUSE (53-776): 3.36e-53: 202: 13.62		PTN11_MOUSE (346-428): 1.05e-19: 96.4: 34.94