HitPredict

Interactor 1: SPTCA (P13395)
Spectrin alpha chain
Gene: alpha-Spec

Interactor 2: FLNA (Q9VEN1)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Filamin-1) (Filamin1)
Gene: cher

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	38944040
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	CH~EF-hand_7, CH~EFhand_Ca_insen, CH~Spectrin
Common GO terms	GO:0003779 - actin binding GO:0005886 - plasma membrane GO:0051015 - actin filament binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2415 Dm			1 2210
+	Dm
		561568 SPTCA_DROME (1-2415): 0: 619: 100.00		SPTCB_DROME (1-299): 1.85e-97: 354: 30.23
+	Rn
		591442 SPTN1_RAT (10-2415): 2.63e-178: 609: 63.94		Q6XD99_RAT (1-270): 5.26e-99: 359: 32.62
+	Hs
		174704 SPTN2_HUMAN (9-1560): 3.16e-61: 236: 18.96		FLNA_HUMAN (224-2080): 0: 731: 27.03
+	Hs
		637462 SPTB2_HUMAN (5-1707): 1.15e-58: 228: 19.92		FLNA_HUMAN (224-2080): 0: 731: 27.03
+	Rn
		591445 SPTN1_RAT (10-2415): 2.63e-178: 609: 63.94		ACTN1_RAT (2-265): 4.76e-99: 344: 30.97
+	Hs
		637503 SPTN1_HUMAN (2-1232): 6.72e-45: 182: 21.48		FLNA_HUMAN (224-2080): 0: 731: 27.03
+	Hs
		540231 SPTB1_HUMAN (237-1897): 9.89e-71: 267: 20.33		SPTB1_HUMAN (1-309): 1.46e-98: 357: 26.75
+	Hs
		174744 SPTN2_HUMAN (9-1560): 3.16e-61: 236: 18.96		SPTB2_HUMAN (1-270): 5.3e-99: 359: 32.62
+	Hs
		1028730 SPTB2_HUMAN (5-1707): 1.15e-58: 228: 19.92		SPTB2_HUMAN (1-270): 5.3e-99: 359: 32.62
+	Mm
		1223935 SPTB2_MOUSE (5-1555): 1.23e-51: 204: 19.64		SPTB2_MOUSE (1-270): 5.29e-99: 359: 32.62
+	Hs
		1028762 SPTN1_HUMAN (2-1232): 6.72e-45: 182: 21.48		SPTB2_HUMAN (1-270): 5.3e-99: 359: 32.62
+	Rn
		1251028 Q6XD99_RAT (5-1555): 3.69e-49: 196: 18.94		ACTN1_RAT (2-265): 4.76e-99: 344: 30.97
+	Hs
		540251 SPTN1_HUMAN (2-1232): 6.72e-45: 182: 21.48		SPTB1_HUMAN (1-309): 1.46e-98: 357: 26.75
+	Hs
		174755 SPTN1_HUMAN (2-1232): 6.72e-45: 182: 21.48		SPTN2_HUMAN (1-270): 9.93e-98: 355: 30.82
+	Hs
		249121 SPTB2_HUMAN (5-1707): 1.15e-58: 228: 19.92		DSCAM_HUMAN (1515-2202): 5.91e-20: 100: 12.17
+	Hs
		174675 SPTN2_HUMAN (9-1560): 3.16e-61: 236: 18.96		OBSL1_HUMAN (1438-2208): 1.2e-16: 89.4: 12.19
+	Hs
		1117369 SPTN1_HUMAN (2-1232): 6.72e-45: 182: 21.48		PLEC_HUMAN (15-235): 6.57e-33: 143: 37.61
+	Hs
		249139 PLEC_HUMAN (1-1338): 7.59e-40: 166: 8.88		DSCAM_HUMAN (1515-2202): 5.91e-20: 100: 12.17
+	Hs
		272198 PLEC_HUMAN (1-1338): 7.59e-40: 166: 8.88		OBSL1_HUMAN (1438-2208): 1.2e-16: 89.4: 12.19